7UHB

SARS-CoV-2 spike in complex with AHB2-2GS-SB175 (local refinement of the RBD and AHB2)

Summary for 7UHB

• Entry DOI: 10.2210/pdb7uhb/pdb
• EMDB information: 26511
• Descriptor: Spike glycoprotein, Multivalent miniprotein inhibitor AHB2-2GS-SB175, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: sars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus; More
• Total number of polymer chains: 2
• Total formula weight: 160563.77

Authors

Park, Y.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID),Veesler, D. (deposition date: 2022-03-26, release date: 2022-06-08)

• Primary citation: Hunt, A.C.,Case, J.B.,Park, Y.J.,Cao, L.,Wu, K.,Walls, A.C.,Liu, Z.,Bowen, J.E.,Yeh, H.W.,Saini, S.,Helms, L.,Zhao, Y.T.,Hsiang, T.Y.,Starr, T.N.,Goreshnik, I.,Kozodoy, L.,Carter, L.,Ravichandran, R.,Green, L.B.,Matochko, W.L.,Thomson, C.A.,Vogeli, B.,Kruger, A.,VanBlargan, L.A.,Chen, R.E.,Ying, B.,Bailey, A.L.,Kafai, N.M.,Boyken, S.E.,Ljubetic, A.,Edman, N.,Ueda, G.,Chow, C.M.,Johnson, M.,Addetia, A.,Navarro, M.J.,Panpradist, N.,Gale Jr., M.,Freedman, B.S.,Bloom, J.D.,Ruohola-Baker, H.,Whelan, S.P.J.,Stewart, L.,Diamond, M.S.,Veesler, D.,Jewett, M.C.,Baker, D.; Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.; Sci Transl Med, 14:eabn1252-eabn1252, 2022; PubMed: 35412328; DOI: 10.1126/scitranslmed.abn1252

Experimental method

ELECTRON MICROSCOPY (3 Å)