7WLT
 
 | | the Curved Structure of mPIEZO1 in Lipid Bilayer | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... | | Authors: | Yang, X, Lin, C, Chen, X, Li, S, Li, X, Xiao, B. | | Deposit date: | 2022-01-13 | | Release date: | 2022-04-13 | | Last modified: | 2022-07-06 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structure deformation and curvature sensing of PIEZO1 in lipid membranes.
Nature, 604, 2022
|
|
7WLU
 | | The Flattened Structure of mPIEZO1 in Lipid Bilayer | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, Piezo-type mechanosensitive ion channel component 1 | | Authors: | Yang, X, Lin, C, Chen, X, Li, S, Li, X, Xiao, B. | | Deposit date: | 2022-01-13 | | Release date: | 2022-04-13 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (6.81 Å) | | Cite: | Structure deformation and curvature sensing of PIEZO1 in lipid membranes.
Nature, 604, 2022
|
|
6BK8
 | | S. cerevisiae spliceosomal post-catalytic P complex | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Lea1, ... | | Authors: | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | | Deposit date: | 2017-11-07 | | Release date: | 2018-02-21 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the yeast spliceosomal postcatalytic P complex.
Science, 358, 2017
|
|
6E7P
 | | cryo-EM structure of human TRPML1 with PI35P2 | | Descriptor: | (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], Mucolipin-1 | | Authors: | Schmiege, P, Li, X. | | Deposit date: | 2018-07-27 | | Release date: | 2018-11-28 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
|
|
6E7Y
 | | cryo-EM structure of human TRPML1 with PI45P2 | | Descriptor: | Mucolipin-1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Schmiege, P, Li, X. | | Deposit date: | 2018-07-27 | | Release date: | 2018-11-28 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.57 Å) | | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
|
|
6K61
 | | Cryo-EM structure of the tetrameric photosystem I from a heterocyst-forming cyanobacterium Anabaena sp. PCC7120 | | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | | Authors: | Zheng, L, Li, Y, Li, X, Zhong, Q, Li, N, Zhang, K, Zhang, Y, Chu, H, Ma, C, Li, G, Zhao, J, Gao, N. | | Deposit date: | 2019-05-31 | | Release date: | 2019-10-09 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.37 Å) | | Cite: | Structural and functional insights into the tetrameric photosystem I from heterocyst-forming cyanobacteria.
Nat.Plants, 5, 2019
|
|
2K3C
 | | Structural and Functional Characterization of TM IX of the NHE1 Isoform of the Na+/H+ Exchanger | | Descriptor: | TMIX peptide | | Authors: | Reddy, T, Ding, J, Li, X, Sykes, B.D, Fliegel, L, Rainey, J.K. | | Deposit date: | 2008-05-01 | | Release date: | 2008-06-03 | | Last modified: | 2024-11-27 | | Method: | SOLUTION NMR | | Cite: | Structural and Functional Characterization of Transmembrane Segment IX of the NHE1 Isoform of the Na+/H+ Exchanger.
J.Biol.Chem., 283, 2008
|
|
6E7Z
 | | cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2 | | Descriptor: | (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1 | | Authors: | Schmiege, P, Li, X. | | Deposit date: | 2018-07-27 | | Release date: | 2018-11-28 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
|
|
7XMW
 | | Crystal structure of anti-CRISPR protein AcrVIA2 | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, AcrVIA2, SELENIUM ATOM, ... | | Authors: | Yan, X, Li, X, Song, G. | | Deposit date: | 2022-04-27 | | Release date: | 2023-05-31 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structure of AcrVIA2 and its binding mechanism to CRISPR-Cas13a.
Biochem.Biophys.Res.Commun., 612, 2022
|
|
3TO8
 | | Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L) | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Heterogeneous nuclear ribonucleoprotein L, ... | | Authors: | Zhang, W.J, Zeng, F.X, Liu, Y.W, Zhao, Y, Niu, L.W, Teng, M.K, Li, X. | | Deposit date: | 2011-09-04 | | Release date: | 2012-03-07 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L)
To be Published
|
|
8IXN
 | | Curved structure of mPIEZO1-S2472E | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... | | Authors: | Liu, S, Yang, X, Chen, X, Li, X, Xiao, B. | | Deposit date: | 2023-04-01 | | Release date: | 2025-01-01 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel.
Neuron, 113, 2025
|
|
8IXO
 | | Intermediate structure of mPIEZO1-S2472E | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... | | Authors: | Liu, S, Yang, X, Chen, X, Li, X, Xiao, B. | | Deposit date: | 2023-04-01 | | Release date: | 2025-01-01 | | Last modified: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel.
Neuron, 113, 2025
|
|
8W9X
 | |
8W9L
 | |
3VBC
 | |
5EBG
 | | Crystal structure of bovine CD8aa homodimer | | Descriptor: | T-cell surface glycoprotein CD8 alpha chain | | Authors: | Liu, Y, Li, X, Zhang, N, Qi, J, Xia, C. | | Deposit date: | 2015-10-19 | | Release date: | 2016-09-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species.
Sci Rep, 6, 2016
|
|
5EG3
 | | Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma) | | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Fibroblast growth factor receptor 2, MAGNESIUM ION, ... | | Authors: | Huang, Z, Li, X, Mohammadi, M. | | Deposit date: | 2015-10-26 | | Release date: | 2016-02-03 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.606 Å) | | Cite: | Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma.
Mol.Cell, 61, 2016
|
|
2G5T
 | | Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ag | | Descriptor: | 3-{[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHOXY}-4-CHLOROBENZOIC ACID, Dipeptidyl peptidase 4 | | Authors: | Longenecker, K.L, Fry, E.H, Lake, M.R, Solomon, L.R, Pei, Z, Li, X. | | Deposit date: | 2006-02-23 | | Release date: | 2006-07-04 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J.Med.Chem., 49, 2006
|
|
8WRB
 | | Lysophosphatidylserine receptor GPR34-Gi complex | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Gong, W, Liu, G, Li, X, Wang, Y, Zhang, X. | | Deposit date: | 2023-10-13 | | Release date: | 2023-11-08 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
Plos Biol., 21, 2023
|
|
8TWU
 | | Crystal structure of Cytochrome P450 AspB bound to N1-methylated cyclo-L-Trp-L-Pro | | Descriptor: | (3S,5S,8aS)-3-[(1-methyl-1H-indol-3-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, Cytochrome P450 AspB, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Gering, H.E, Li, X, Tang, H, Swartz, P.D, Chang, W.-C, Makris, T.M. | | Deposit date: | 2023-08-21 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization.
J.Am.Chem.Soc., 145, 2023
|
|
2G5P
 | | Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ac | | Descriptor: | 4-{[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHOXY}-3-TERT-BUTYLBENZOIC ACID, Dipeptidyl peptidase 4 | | Authors: | Longenecker, K.L, Fry, E.H, Lake, M.R, Solomon, L.R, Pei, Z, Li, X. | | Deposit date: | 2006-02-23 | | Release date: | 2006-07-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J.Med.Chem., 49, 2006
|
|
2G63
 | | Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 24b | | Descriptor: | Dipeptidyl peptidase 4, METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE | | Authors: | Longenecker, K.L, Fry, E.H, Lake, M.R, Solomon, L.R, Pei, Z, Li, X. | | Deposit date: | 2006-02-24 | | Release date: | 2006-07-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J.Med.Chem., 49, 2006
|
|
8WYI
 | | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | | Descriptor: | Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-31 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
|
|
8WY0
 | | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-30 | | Release date: | 2024-05-08 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
|
|
8WXE
 | | Vgamma5Vdelta1 EH TCR-CD3 complex | | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-28 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
|
|
