Summary for 2G5P
| Related | 2G5T |
|---|---|
| Descriptor | Dipeptidyl peptidase 4, 4-{[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHOXY}-3-TERT-BUTYLBENZOIC ACID (3 entities in total) |
| Functional Keywords | serine peptidase, beta-propeller, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Dipeptidyl peptidase 4 soluble form: Secreted . Cell membrane ; Single- pass type II membrane protein P27487 |
| Total number of polymer chains | 2 |
| Total molecular weight | 168908.19 |
| Authors | Longenecker, K.L.,Fry, E.H.,Lake, M.R.,Solomon, L.R.,Pei, Z.,Li, X. (deposition date: 2006-02-23, release date: 2006-07-04, Last modification date: 2017-10-18) |
| Primary citation | Pei, Z.,Li, X.,Longenecker, K.,Von Geldern, T.W.,Wiedeman, P.E.,Lubben, T.H.,Zinker, B.A.,Stewart, K.,Ballaron, S.J.,Stashko, M.A.,Mika, A.K.,Beno, D.W.,Long, M.,Wells, H.,Kempf-Grote, A.J.,Madar, D.J.,McDermott, T.S.,Bhagavatula, L.,Fickes, M.G.,Pireh, D.,Solomon, L.R.,Lake, M.R.,Edalji, R.,Fry, E.H.,Sham, H.L.,Trevillyan, J.M. Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors. J.Med.Chem., 49:3520-3535, 2006 PubMed: 16759095 (PDB entries with the same primary citation) DOI: 10.1021/jm051283e  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
