3R6K
 
 | | Crystal Structure of the Capsid P Domain from Norwalk Virus Strain Hiroshima/1999 in complex with HBGA type B (triglycan) | | Descriptor: | 1,2-ETHANEDIOL, VP1 protein, alpha-L-fucopyranose-(1-2)-[alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose | | Authors: | Hansman, G.S, Biertumpfel, C, McLellan, J.S, Georgiev, I, Chen, L, Zhou, T, Katayama, K, Kwong, P.D. | | Deposit date: | 2011-03-21 | | Release date: | 2011-05-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability.
J.Virol., 85, 2011
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3RRT
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3RRR
 | | Structure of the RSV F protein in the post-fusion conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0 | | Authors: | McLellan, J.S, Yongping, Y, Graham, B.S, Kwong, P.D. | | Deposit date: | 2011-04-30 | | Release date: | 2011-06-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.821 Å) | | Cite: | Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
J.Virol., 85, 2011
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3R0M
 | | Crystal structure of anti-HIV llama VHH antibody A12 | | Descriptor: | Llama VHH A12, SULFATE ION | | Authors: | Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D. | | Deposit date: | 2011-03-08 | | Release date: | 2012-03-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Single-Headed Immunoglobulins Efficiently Penetrate CD4-Binding Site and Effectively Neutralize HIV-1
To be Published
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3U46
 | | CH04H/CH02L P212121 | | Descriptor: | CH02 Light chain Fab, CH04 Heavy chain Fab | | Authors: | Louder, R, Pancera, M, McLellan, J.S, Kwong, P.D. | | Deposit date: | 2011-10-07 | | Release date: | 2011-11-30 | | Last modified: | 2011-12-21 | | Method: | X-RAY DIFFRACTION (2.906 Å) | | Cite: | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Nature, 480, 2011
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3U4E
 | | Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain CAP45 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG9 Heavy Chain, PG9 Light Chain, ... | | Authors: | Gorman, J, McLellan, J, Pancera, M, Kwong, P.D. | | Deposit date: | 2011-10-07 | | Release date: | 2011-11-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.185 Å) | | Cite: | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Nature, 480, 2011
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3U2S
 | | Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 | | Descriptor: | (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | Authors: | McLellan, J.S, Pancera, M, Kwong, P.D. | | Deposit date: | 2011-10-04 | | Release date: | 2011-11-30 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.797 Å) | | Cite: | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Nature, 480, 2011
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8EK1
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8EKA
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8D21
 | | Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer | | Descriptor: | 1B06 Heavy Chain, 1B06 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Gorman, J, Kwong, P.D. | | Deposit date: | 2022-05-27 | | Release date: | 2023-04-12 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans.
Sci Transl Med, 15, 2023
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8D9Y
 | | Crystal structure of Taipan alpha-neurotoxin in complex with Centi-LNX-D09 antibody | | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Centi-LNX-D09 Fab heavy chain, ... | | Authors: | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | Deposit date: | 2022-06-12 | | Release date: | 2023-06-14 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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8D9Z
 | | Crystal structure of Cobra alpha-neurotoxin in complex with Centi-LNX-D09 antibody | | Descriptor: | ACETATE ION, Centi-LNX-D09 Fab heavy chain, Centi-LNX-D09 Fab light chain, ... | | Authors: | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | Deposit date: | 2022-06-12 | | Release date: | 2023-06-14 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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8DA1
 | | Crystal structure of Krait alpha-neurotoxin in complex with Centi-LNX-D09 antibody | | Descriptor: | Alpha-bungarotoxin, Centi-LNX-D09 Fab heavy chain, Centi-LNX-D09 Fab light chain | | Authors: | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | Deposit date: | 2022-06-12 | | Release date: | 2023-06-14 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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8DA0
 | | Crystal structure of Mamba alpha-neurotoxin in complex with Centi-LNX-D09 antibody | | Descriptor: | ACETATE ION, Alpha-elapitoxin-Dpp2d, Centi-LNX-D09 Fab heavy chain, ... | | Authors: | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | Deposit date: | 2022-06-12 | | Release date: | 2023-06-14 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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8DEF
 | | Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW24 fab | | Descriptor: | SKW24 Fab heavy chain, SKW24 Fab light chain, Spike glycoprotein E1, ... | | Authors: | Pletnev, S, Tsybovsky, Y, Verardi, R, Roedeger, M, Kwong, P.D. | | Deposit date: | 2022-06-20 | | Release date: | 2023-07-05 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
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8DUA
 | | SIV E660.CR54 SOS-2P Env Trimer with ITS92.02 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, Envelope glycoprotein gp41, ... | | Authors: | Gorman, J, Kwong, P.D. | | Deposit date: | 2022-07-27 | | Release date: | 2022-10-26 | | Last modified: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (4.32 Å) | | Cite: | Cryo-EM structures of prefusion SIV envelope trimer.
Nat.Struct.Mol.Biol., 29, 2022
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8DVD
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8DW2
 | | Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022 | | Descriptor: | Antibody CR3022 heavy chain, Antibody CR3022 light chain, Antibody S309 heavy chain, ... | | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | | Deposit date: | 2022-07-30 | | Release date: | 2022-12-07 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (4.11 Å) | | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.
Nat.Chem.Biol., 19, 2023
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8DW3
 | | Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022 | | Descriptor: | Anti-SARS-CoV-2 DARPin SR16m, Antibody S309 light chain, Spike protein S1, ... | | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | | Deposit date: | 2022-07-30 | | Release date: | 2022-12-07 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (4.26 Å) | | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.
Nat.Chem.Biol., 19, 2023
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6UBI
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6TYB
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6UCE
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6UCF
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6URM
 | | Crystal structure of vaccine-elicited receptor-binding site targeting antibody LPAF-a.01 in complex with Hemagglutinin H1 A/California/04/2009 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Zhou, T, Cheung, S.F, Kwong, P.D. | | Deposit date: | 2019-10-23 | | Release date: | 2020-09-16 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.
Cell Rep, 32, 2020
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6VI0
 | | Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 gp120, ... | | Authors: | Gorman, J, Kwong, P.D. | | Deposit date: | 2020-01-10 | | Release date: | 2021-01-13 | | Last modified: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention.
Mabs, 13
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