6TYB

Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields

Summary for 6TYB

Entry DOI	10.2210/pdb6tyb/pdb
Descriptor	Envelope glycoprotein gp160, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
Functional Keywords	bnabs, gp120, fab, immune system, glycan
Biological source	Simian immunodeficiency virus (SIV) More
Total number of polymer chains	4
Total formula weight	120509.04
Authors	Gorman, J.,Kwong, P.D. (deposition date: 2019-08-08, release date: 2019-10-02, Last modification date: 2023-10-11)
Primary citation	Gorman, J.,Mason, R.D.,Nettey, L.,Cavett, N.,Chuang, G.Y.,Peng, D.,Tsybovsky, Y.,Verardi, R.,Nguyen, R.,Ambrozak, D.,Biris, K.,LaBranche, C.C.,Ramesh, A.,Schramm, C.A.,Zhou, J.,Bailer, R.T.,Kepler, T.B.,Montefiori, D.C.,Shapiro, L.,Douek, D.C.,Mascola, J.R.,Roederer, M.,Kwong, P.D. Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields. Immunity, 51:724-, 2019 Cited by PubMed: 31586542 DOI: 10.1016/j.immuni.2019.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.301 Å)

Structure validation