8D21

Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer

Summary for 8D21

• Entry DOI: 10.2210/pdb8d21/pdb
• EMDB information: 27139
• Descriptor: Hemagglutinin HA2 chain, Hemagglutinin HA1 chain, 1B06 Heavy Chain, ... (6 entities in total)
• Functional Keywords: vrc, immune system, vrc321, fab, stem, immune system-viral protein complex, immune system/viral protein
• Biological source: Influenza A virus; More
• Total number of polymer chains: 12
• Total formula weight: 267249.50

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2022-05-27, release date: 2023-04-12, Last modification date: 2023-05-03)

• Primary citation: Andrews, S.F.,Cominsky, L.Y.,Shimberg, G.D.,Gillespie, R.A.,Gorman, J.,Raab, J.E.,Brand, J.,Creanga, A.,Gajjala, S.R.,Narpala, S.,Cheung, C.S.F.,Harris, D.R.,Zhou, T.,Gordon, I.,Holman, L.,Mendoza, F.,Houser, K.V.,Chen, G.L.,Mascola, J.R.,Graham, B.S.,Kwong, P.D.,Widge, A.,Dropulic, L.K.,Ledgerwood, J.E.,Kanekiyo, M.,McDermott, A.B.; An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans.; Sci Transl Med, 15:eade4976-eade4976, 2023; PubMed: 37075126; DOI: 10.1126/scitranslmed.ade4976

Experimental method

ELECTRON MICROSCOPY (3.96 Å)