8DVD

Cryo-EM structure of SIVmac239 SOS-2P Env trimer in complex with human bNAb PGT145

This is a non-PDB format compatible entry.

Summary for 8DVD

• Entry DOI: 10.2210/pdb8dvd/pdb
• Related: 8DUA
• EMDB information: 27631 27735
• Descriptor: Envelope glycoprotein gp160, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• Functional Keywords: cd4, hiv-1, sosip, vaccine, immune system, siv, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Simian immunodeficiency virus; More
• Total number of polymer chains: 8
• Total formula weight: 328770.53

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2022-07-28, release date: 2022-11-16, Last modification date: 2022-11-30)

• Primary citation: Gorman, J.,Wang, C.,Mason, R.D.,Nazzari, A.F.,Welles, H.C.,Zhou, T.,Bess Jr., J.W.,Bylund, T.,Lee, M.,Tsybovsky, Y.,Verardi, R.,Wang, S.,Yang, Y.,Zhang, B.,Rawi, R.,Keele, B.F.,Lifson, J.D.,Liu, J.,Roederer, M.,Kwong, P.D.; Cryo-EM structures of prefusion SIV envelope trimer.; Nat.Struct.Mol.Biol., 29:1080-1091, 2022; PubMed: 36344847; DOI: 10.1038/s41594-022-00852-1

Experimental method

ELECTRON MICROSCOPY (4.12 Å)