4ZIL
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![BU of 4zil by Molmil](/molmil-images/mine/4zil) | Crystal structure of Rv2466c and oxidoreductase from Mycobacterium tuberculosis in its reduced state | Descriptor: | DSBA oxidoreductase, MAGNESIUM ION | Authors: | Albesa-Jove, D, Urresti, S, Comino, N, Tersa, M, Guerin, M.E. | Deposit date: | 2015-04-28 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.507 Å) | Cite: | The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053. J.Biol.Chem., 290, 2015
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4ZDJ
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![BU of 4zdj by Molmil](/molmil-images/mine/4zdj) | Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules | Descriptor: | CTP synthase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Bellinzoni, M, Barilone, N, Alzari, P.M. | Deposit date: | 2015-04-17 | Release date: | 2015-07-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
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4ZDI
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4ZDK
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![BU of 4zdk by Molmil](/molmil-images/mine/4zdk) | Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine | Descriptor: | 5-OXO-L-NORLEUCINE, CTP synthase, MAGNESIUM ION, ... | Authors: | Bellinzoni, M, Barilone, N, Alzari, P.M. | Deposit date: | 2015-04-17 | Release date: | 2015-07-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
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3V9M
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![BU of 3v9m by Molmil](/molmil-images/mine/3v9m) | Phospholipase ACII4 from Australian King Brown Snake | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Guddat, L.W, Millers, E.K. | Deposit date: | 2011-12-27 | Release date: | 2013-02-13 | Method: | X-RAY DIFFRACTION (1.563 Å) | Cite: | Mechanistic studies on the anticoagulant activity of a phospholipase A2 from the venom of the Australian King Brown Snake (Pseudechis australis) To be Published
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7S49
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![BU of 7s49 by Molmil](/molmil-images/mine/7s49) | Crystal Structure of Inhibitor-bound Galactokinase | Descriptor: | (4R)-2-[(1,3-benzoxazol-2-yl)amino]-4-(4-chloro-1H-pyrazol-5-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one, Galactokinase, PHOSPHATE ION, ... | Authors: | Whitby, F.G. | Deposit date: | 2021-09-08 | Release date: | 2021-09-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J.Med.Chem., 64, 2021
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7S4C
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![BU of 7s4c by Molmil](/molmil-images/mine/7s4c) | Crystal Structure of Inhibitor-bound Galactokinase | Descriptor: | 2-({(4R)-4-(2-chlorophenyl)-2-[(6-fluoro-1,3-benzoxazol-2-yl)amino]-6-methyl-1,4-dihydropyrimidine-5-carbonyl}amino)pyridine-4-carboxylic acid, Galactokinase, PHOSPHATE ION, ... | Authors: | Whitby, F.G. | Deposit date: | 2021-09-08 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J.Med.Chem., 64, 2021
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3J1A
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![BU of 3j1a by Molmil](/molmil-images/mine/3j1a) | HK97-like fold fitted into 3D reconstruction of bacteriophage CW02 | Descriptor: | capsid protein | Authors: | Shen, P.S, Domek, M.J, Sanz-Garcia, E, Makaju, A, Taylor, R, Culumber, M, Breakwell, D.P, Prince, J.T, Belnap, D.M. | Deposit date: | 2012-01-31 | Release date: | 2012-05-30 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (16 Å) | Cite: | Sequence and Structural Characterization of Great Salt Lake Bacteriophage CW02, a Member of the T7-Like Supergroup. J.Virol., 86, 2012
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6U6U
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![BU of 6u6u by Molmil](/molmil-images/mine/6u6u) | IL36R extracellular domain in complex with BI655130 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BI00655130 Fab heavy chain, ... | Authors: | Larson, E.T, Farrow, N.A. | Deposit date: | 2019-08-30 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains. Protein Sci., 29, 2020
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2MT7
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![BU of 2mt7 by Molmil](/molmil-images/mine/2mt7) | |
2OKW
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5WDP
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![BU of 5wdp by Molmil](/molmil-images/mine/5wdp) | H-Ras mutant L120A bound to GMP-PNP at 277K | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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6AOW
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5WDO
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![BU of 5wdo by Molmil](/molmil-images/mine/5wdo) | H-Ras bound to GMP-PNP at 277K | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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6AOX
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6AS8
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6AZX
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![BU of 6azx by Molmil](/molmil-images/mine/6azx) | Crystal structure of the neutralizing anti-circumsporozoite protein 663 antibody | Descriptor: | 663 antibody, heavy chain, light chain | Authors: | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-13 | Release date: | 2017-12-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity, 47, 2017
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6ARM
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6ARN
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![BU of 6arn by Molmil](/molmil-images/mine/6arn) | |
6AZM
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![BU of 6azm by Molmil](/molmil-images/mine/6azm) | Crystal structure of the 580 germline antibody bound to circumsporozoite protein NANP 5-mer | Descriptor: | 580 germline antibody, heavy chain, light chain, ... | Authors: | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-11 | Release date: | 2017-12-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity, 47, 2017
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6AOY
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5J94
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![BU of 5j94 by Molmil](/molmil-images/mine/5j94) | Human cathepsin K mutant C25S in complex with the allosteric effector NSC13345 | Descriptor: | 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, Cathepsin K, SULFATE ION | Authors: | Novinec, M, Korenc, M, Lenarcic, B, Baici, A. | Deposit date: | 2016-04-08 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.22002459 Å) | Cite: | A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods. Nat Commun, 5, 2014
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5JBQ
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5WDS
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![BU of 5wds by Molmil](/molmil-images/mine/5wds) | Choanoflagellate Salpingoeca rosetta Ras with GDP bound | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Kondo, Y, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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5WDQ
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![BU of 5wdq by Molmil](/molmil-images/mine/5wdq) | H-Ras mutant L120A bound to GMP-PNP at 100K | Descriptor: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | Authors: | Bandaru, P, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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