6U6U

IL36R extracellular domain in complex with BI655130 Fab

Summary for 6U6U

• Entry DOI: 10.2210/pdb6u6u/pdb
• Descriptor: BI00655130 Fab heavy chain, BI00655130 Fab light chain, Interleukin-1 receptor-like 2, ... (7 entities in total)
• Functional Keywords: il36r, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 70478.09

Authors

Larson, E.T.,Farrow, N.A. (deposition date: 2019-08-30, release date: 2020-04-22, Last modification date: 2023-10-11)

• Primary citation: Larson, E.T.,Brennan, D.L.,Hickey, E.R.,Ganesan, R.,Kroe-Barrett, R.,Farrow, N.A.; X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains.; Protein Sci., 29:1679-1686, 2020; PubMed: 32239732; DOI: 10.1002/pro.3862

Experimental method

X-RAY DIFFRACTION (2.31 Å)