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6LW0
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BU of 6lw0 by Molmil
Crystal structure of TLR7/Cpd-6 (DSR-139293) complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2020-02-06
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LVY
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BU of 6lvy by Molmil
Crystal structure of TLR7/Cpd-2 (SM-360320) complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2020-02-06
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
5H6V
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BU of 5h6v by Molmil
Structure of Zika virus protease in complex with a dipeptide inhibitor
Descriptor: (S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide, Genome polyprotein
Authors:Zhang, Z, Chen, M.
Deposit date:2016-11-15
Release date:2017-06-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.422 Å)
Cite:Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors
Structure, 25, 2017
5H93
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BU of 5h93 by Molmil
Crystal structure of Geobacter metallireducens SMUG1
Descriptor: Geobacter metallireducens SMUG1
Authors:Xie, W, Cao, W, Zhang, Z, Shen, J.
Deposit date:2015-12-25
Release date:2016-04-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.176 Å)
Cite:Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1
Acs Chem.Biol., 11, 2016
5H98
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BU of 5h98 by Molmil
Crystal structure of Geobacter metallireducens SMUG1
Descriptor: Geobacter metallireducens SMUG1
Authors:Xie, W, Cao, W, Zhang, Z, Shen, J.
Deposit date:2015-12-26
Release date:2016-04-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1
Acs Chem.Biol., 11, 2016
5H99
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BU of 5h99 by Molmil
Crystal structure of Geobacter metallireducens SMUG1 mutant N58D
Descriptor: Geobacter metallireducens SMUG1
Authors:Xie, W, Cao, W, Zhang, Z, Shen, J.
Deposit date:2015-12-26
Release date:2016-04-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1
Acs Chem.Biol., 11, 2016
5H9I
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BU of 5h9i by Molmil
Crystal structure of Geobacter metallireducens SMUG1 with xanthine
Descriptor: BETA-MERCAPTOETHANOL, GLYCEROL, Geobacter metallireducens SMUG1, ...
Authors:Xie, W, Cao, W, Zhang, Z, Shen, J.
Deposit date:2015-12-28
Release date:2016-04-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1
Acs Chem.Biol., 11, 2016
8GS4
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BU of 8gs4 by Molmil
Cryo-EM structure of human Neuroligin 2
Descriptor: Neuroligin-2
Authors:Zhang, H, Zhang, Z, Hou, M.
Deposit date:2022-09-04
Release date:2023-03-01
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.
Front Endocrinol, 13, 2022
8GS3
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BU of 8gs3 by Molmil
Cryo-EM structure of human Neuroligin 3
Descriptor: Neuroligin-3
Authors:Zhang, H, Zhang, Z, Hou, M.
Deposit date:2022-09-04
Release date:2023-09-20
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.
Front Endocrinol, 13, 2022
7DEU
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BU of 7deu by Molmil
Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody scFv
Authors:Zhang, Z, Zhang, G, Li, X, Rao, Z, Guo, Y.
Deposit date:2020-11-05
Release date:2021-03-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes.
Plos Biol., 19, 2021
7Y0W
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BU of 7y0w by Molmil
Local structure of BD55-5514 and BD55-5840 Fab and Omicron BA.1 RBD complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-5514H, BD55-5514L, ...
Authors:Zhang, Z, Xiao, J.
Deposit date:2022-06-06
Release date:2022-09-28
Last modified:2023-04-12
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents.
Cell Rep, 41, 2022
7Y0C
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BU of 7y0c by Molmil
Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-1403 Fab heavy chain, BD55-1403 Fab light chain, ...
Authors:Zhang, Z, Xiao, J.
Deposit date:2022-06-04
Release date:2022-09-28
Last modified:2023-04-12
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents.
Cell Rep, 41, 2022
8T4V
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BU of 8t4v by Molmil
Crystal structure of compound 1 bound to K-Ras(G12D)
Descriptor: 4-{(1R,5S)-3-[(7P)-7-(8-ethynylnaphthalen-1-yl)-8-fluoro-2-{[(4s,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl}-4-oxobutanoic acid, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Zhang, Z, Zheng, Q, Guiley, K.Z, Shokat, K.M.
Deposit date:2023-06-10
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
Nat.Chem.Biol., 2024
8WX3
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BU of 8wx3 by Molmil
Cryo-EM structure of human SLC15A4 (outward-facing open)
Descriptor: Solute carrier family 15 member 4
Authors:Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2023-10-27
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Cryo-EM structure of human SLC15A4 (outward-facing open)
To Be Published
8WX2
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BU of 8wx2 by Molmil
Cryo-EM structure of human SLC15A3 (dimer)
Descriptor: Solute carrier family 15 member 3
Authors:Kasai, S, Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2023-10-27
Release date:2023-12-06
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)
To Be Published
8WX5
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BU of 8wx5 by Molmil
Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
Descriptor: Solute carrier family 15 member 4, TASL (TASL-SLC15A4 fusion protein)
Authors:Ohto, U, Zhang, Z, Fujimura, A, Shimizu, T.
Deposit date:2023-10-27
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
To Be Published
8WX4
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BU of 8wx4 by Molmil
Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
Descriptor: LEUCINE, LYSINE, Solute carrier family 15 member 4
Authors:Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2023-10-27
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
To Be Published
8HIJ
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BU of 8hij by Molmil
The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex
Descriptor: Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ...
Authors:Zhang, Z, Dang, Y.
Deposit date:2022-11-20
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Molecular mechanism of substrate recognition by folate transporter SLC19A1.
Cell Discov, 8, 2022
8HII
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BU of 8hii by Molmil
The BRIL-SLC19A1/Fab/Nb ternary complex
Descriptor: BRIL-SLC19A1 chimera, anti-BRIL Fab heavy chain, anti-BRIL Fab light chain, ...
Authors:Zhang, Z, Dang, Y.
Deposit date:2022-11-20
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Molecular mechanism of substrate recognition by folate transporter SLC19A1.
Cell Discov, 8, 2022
8HIK
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BU of 8hik by Molmil
The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex
Descriptor: Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ...
Authors:Zhang, Z, Dang, Y.
Deposit date:2022-11-20
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Molecular mechanism of substrate recognition by folate transporter SLC19A1.
Cell Discov, 8, 2022
8HGO
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BU of 8hgo by Molmil
The EGF-bound EGFR/HER2 ectodomain complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor, ...
Authors:Zhang, Z, Bai, X.
Deposit date:2022-11-15
Release date:2023-02-08
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
8HGS
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BU of 8hgs by Molmil
The EGF-bound EGFR ectodomain homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Pro-epidermal growth factor, ...
Authors:Zhang, Z, Bai, X.
Deposit date:2022-11-15
Release date:2023-02-15
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.81 Å)
Cite:Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
8HGP
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BU of 8hgp by Molmil
The EREG-bound EGFR/HER2 ectodomain complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
Authors:Zhang, Z, Bai, X.
Deposit date:2022-11-15
Release date:2023-02-08
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (4.53 Å)
Cite:Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
7E7X
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BU of 7e7x by Molmil
SARS-CoV-2 Spike Protein N terminal domain in Complex with N11 Fab
Descriptor: N11 Fab Light chain, N11 Fab heavy chain, Spike protein S1
Authors:Zhang, Z, Shuo, D, Xiao, J.
Deposit date:2021-02-28
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.
Cell Res., 31, 2021
7UZM
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BU of 7uzm by Molmil
Glutamate dehydrogenase 1 from human liver
Descriptor: Glutamate dehydrogenase 1, mitochondrial
Authors:Zhang, Z.
Deposit date:2022-05-09
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023

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數據於2024-06-26公開中

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