6K9M

Human LXR-beta in complex with an agonist

Summary for 6K9M

• Entry DOI: 10.2210/pdb6k9m/pdb
• Descriptor: Oxysterols receptor LXR-beta, ~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-propan-2-yl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate (3 entities in total)
• Functional Keywords: nuclear receptor, dna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 126008.04

Authors

Zhang, Z.,Zhou, H. (deposition date: 2019-06-16, release date: 2020-06-17, Last modification date: 2023-11-22)

• Primary citation: Chen, Z.,Chen, H.,Zhang, Z.,Ding, P.,Yan, X.,Li, Y.,Zhang, S.,Gu, Q.,Zhou, H.,Xu, J.; Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors.; Eur.J.Med.Chem., 206:112793-112793, 2020; PubMed: 32961480; DOI: 10.1016/j.ejmech.2020.112793

Experimental method

X-RAY DIFFRACTION (2.9 Å)