6K9G

Human LXR-beta in complex with an agonist

Summary for 6K9G

• Entry DOI: 10.2210/pdb6k9g/pdb
• Descriptor: Oxysterols receptor LXR-beta, ~{tert}-butyl (2'~{R},3~{R})-2'-[3-[4-(hydroxymethyl)-3-methylsulfonyl-phenyl]phenyl]-2-oxidanylidene-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate (3 entities in total)
• Functional Keywords: nuclear receptor, dna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 126880.95

Authors

Zhang, Z.,Zhou, H. (deposition date: 2019-06-15, release date: 2020-04-22, Last modification date: 2023-11-22)

• Primary citation: Chen, H.,Chen, Z.,Zhang, Z.,Li, Y.,Zhang, S.,Jiang, F.,Wei, J.,Ding, P.,Zhou, H.,Gu, Q.,Xu, J.; Discovery of new LXR beta agonists as glioblastoma inhibitors.; Eur.J.Med.Chem., 194:112240-112240, 2020; PubMed: 32248003; DOI: 10.1016/j.ejmech.2020.112240

Experimental method

X-RAY DIFFRACTION (2.8 Å)