1VOK
 
 | | ARABIDOPSIS THALIANA TBP (DIMER) | | Descriptor: | SULFATE ION, TATA-BOX-BINDING PROTEIN | | Authors: | Nikolov, D.B, Burley, S.K. | | Deposit date: | 1996-04-29 | | Release date: | 1996-11-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | 2.1 A resolution refined structure of a TATA box-binding protein (TBP).
Nat.Struct.Biol., 1, 1994
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1VOL
 | | TFIIB (HUMAN CORE DOMAIN)/TBP (A.THALIANA)/TATA ELEMENT TERNARY COMPLEX | | Descriptor: | DNA (5'-D(*CP*AP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ... | | Authors: | Nikolov, D.B, Chen, H, Halay, E.D, Usheva, A.U, Hisatake, K, Lee, D.K, Roeder, R.G, Burley, S.K. | | Deposit date: | 1996-04-29 | | Release date: | 1996-11-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of a TFIIB-TBP-TATA-element ternary complex.
Nature, 377, 1995
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1CDW
 | | HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA | | Descriptor: | DNA (5'-D(*CP*AP*GP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)) | | Authors: | Nikolov, D.B, Chen, H, Halay, E.D, Hoffmann, A, Roeder, R.G, Burley, S.K. | | Deposit date: | 1996-04-11 | | Release date: | 1996-12-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a human TATA box-binding protein/TATA element complex.
Proc.Natl.Acad.Sci.USA, 93, 1996
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8GH4
 | | Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody heavy chain, Antibody light chain, ... | | Authors: | Nikolov, D.B, Saha, N, Xu, K, Goldgur, Y. | | Deposit date: | 2023-03-09 | | Release date: | 2023-08-30 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells.
Biomed Pharmacother, 161, 2023
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7S7K
 | | Crystal structure of the EphB2 extracellular domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 2, ... | | Authors: | Xu, Y, Xu, K, Nikolov, D.B. | | Deposit date: | 2021-09-16 | | Release date: | 2021-10-27 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism.
Int J Mol Sci, 22, 2021
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3D11
 | | Crystal Structures of the Nipah G Attachment Glycoprotein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin-neuraminidase, ... | | Authors: | Xu, K, Rajashankar, K.R, Chan, Y.P, Himanen, P, Broder, C.C, Nikolov, D.B. | | Deposit date: | 2008-05-02 | | Release date: | 2008-08-19 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.306 Å) | | Cite: | Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3.
Proc.Natl.Acad.Sci.USA, 105, 2008
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3D12
 | | Crystal Structures of Nipah Virus G Attachment Glycoprotein in Complex with its Receptor Ephrin-B3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin-B3, ... | | Authors: | Xu, K, Rajashankar, K.R, Chan, Y.P, Himanen, P, Broder, C.C, Nikolov, D.B. | | Deposit date: | 2008-05-02 | | Release date: | 2008-08-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.005 Å) | | Cite: | Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3.
Proc.Natl.Acad.Sci.USA, 105, 2008
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5EVM
 | | Crystal Structure of Nipah Virus Fusion Glycoprotein in the Prefusion State | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, MALONATE ION, ... | | Authors: | Xu, K, Nikolov, D.B. | | Deposit date: | 2015-11-20 | | Release date: | 2015-12-16 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.367 Å) | | Cite: | Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly.
Plos Pathog., 11, 2015
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9E6K
 | | Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells. | | Descriptor: | Disintegrin and metalloproteinase domain-containing protein 17, heavy chain of monoclonal antibody C12, light chain monoclonal antibody C12 | | Authors: | Saha, N, De La Cruz, M.J, Goldgur, Y, Nikolov, D.B. | | Deposit date: | 2024-10-30 | | Release date: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells.
Biomed Pharmacother, 180, 2024
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6PD4
 | | Crystal Structure of Hendra Virus Attachment G Glycoprotein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Attachment glycoprotein, ... | | Authors: | Xu, K, Nikolov, D.B. | | Deposit date: | 2019-06-18 | | Release date: | 2019-11-27 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.
PLoS ONE, 7, 2012
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6PDL
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5L0Q
 | | Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Disintegrin and metalloproteinase domain-containing protein 10, MAGNESIUM ION, ... | | Authors: | Xu, K, Saha, N, Nikolov, D.B. | | Deposit date: | 2016-07-28 | | Release date: | 2016-11-09 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.759 Å) | | Cite: | An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
J.Exp.Med., 213, 2016
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3MX0
 | | Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 2, ... | | Authors: | Himanen, J.P, Yermekbayeva, L, Janes, P.W, Walker, J.R, Xu, K, Atapattu, L, Rajashankar, K.R, Mensinga, A, Lackmann, M, Nikolov, D.B, Dhe-Paganon, S. | | Deposit date: | 2010-05-06 | | Release date: | 2010-06-30 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.506 Å) | | Cite: | Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1SHX
 | | Ephrin A5 ligand structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin-A5 | | Authors: | Himanen, J.P, Barton, W.A, Nikolov, D.B, Jeffrey, P.D. | | Deposit date: | 2004-02-26 | | Release date: | 2005-04-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.
J.Biol.Chem., 280, 2005
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4M4R
 | | Epha4 ectodomain complex with ephrin a5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 4, ... | | Authors: | Xu, K, Tsvetkova-Robev, D, Xu, Y, Goldgur, Y, Chan, Y.-P, Himanen, J.P, Nikolov, D.B. | | Deposit date: | 2013-08-07 | | Release date: | 2013-10-30 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (3.13 Å) | | Cite: | Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4M4P
 | | Crystal structure of EPHA4 ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 4 | | Authors: | Xu, K, Tsvetkova-Robev, D, Xu, Y, Goldgur, Y, Chan, Y.-P, Himanen, J.P, Nikolov, D.B. | | Deposit date: | 2013-08-07 | | Release date: | 2013-10-30 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.081 Å) | | Cite: | Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA, 110, 2013
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1VTL
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3HEI
 | | Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex | | Descriptor: | Ephrin type-A receptor 2, Ephrin-A1 | | Authors: | Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B. | | Deposit date: | 2009-05-08 | | Release date: | 2009-06-30 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
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3HPN
 | | Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex | | Descriptor: | Ephrin type-A receptor 2 | | Authors: | Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B. | | Deposit date: | 2009-06-04 | | Release date: | 2009-06-30 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
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2GY5
 | | Tie2 Ligand-Binding Domain Crystal Structure | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ... | | Authors: | Barton, W.A, Nikolov, D.B. | | Deposit date: | 2006-05-09 | | Release date: | 2006-06-06 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.
Nat.Struct.Mol.Biol., 13, 2006
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2GY7
 | | Angiopoietin-2/Tie2 Complex Crystal Structure | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Barton, W.A, Nikolov, D.B. | | Deposit date: | 2006-05-09 | | Release date: | 2006-06-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.
Nat.Struct.Mol.Biol., 13, 2006
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1MP3
 | | L89T VARIANT OF S. ENTERICA RmlA | | Descriptor: | GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, THYMIDINE-5'-TRIPHOSPHATE | | Authors: | Barton, W.A, Biggins, J.B, Jiang, J, Thorson, J.T, Nikolov, D.B. | | Deposit date: | 2002-09-11 | | Release date: | 2002-10-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering
Proc.Natl.Acad.Sci.USA, 99, 2002
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1N2F
 | | CRYSTAL STRUCTURE OF P. AERUGINOSA OHR | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Organic Hydroperoxide Resistance Protein | | Authors: | Lesniak, J, Barton, W.A, Nikolov, D.B. | | Deposit date: | 2002-10-22 | | Release date: | 2002-12-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr
Embo J., 21, 2002
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6P72
 | | Crystal Structure of the Cedar henipavirus Attachment G Glycoprotein global domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Attachment glycoprotein, ... | | Authors: | Xu, K, Nikolov, D.B, Xu, Y. | | Deposit date: | 2019-06-04 | | Release date: | 2019-09-25 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.283 Å) | | Cite: | Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus.
Proc.Natl.Acad.Sci.USA, 116, 2019
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2AO7
 | | Adam10 Disintegrin and cysteine- rich domain | | Descriptor: | ADAM 10, SULFATE ION | | Authors: | Janes, P.W, Saha, N, Barton, W.A, Kolev, M.V, Wimmer-Kleikamp, S.H, Nievergall, E, Blobel, C.P, Himanen, J.-P, Lackmann, M, Nikolov, D.B. | | Deposit date: | 2005-08-12 | | Release date: | 2006-08-08 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.
Cell(Cambridge,Mass.), 123, 2005
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