8GH4

Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody

Summary for 8GH4

• Entry DOI: 10.2210/pdb8gh4/pdb
• Descriptor: Antibody heavy chain, Antibody light chain, Disintegrin and metalloproteinase domain-containing protein 10, ... (4 entities in total)
• Functional Keywords: colorectal cancer, adam 10, human monoclonal antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 68906.23

Authors

Nikolov, D.B.,Saha, N.,Xu, K.,Goldgur, Y. (deposition date: 2023-03-09, release date: 2023-08-30)

• Primary citation: Saha, N.,Baek, D.S.,Mendoza, R.P.,Robev, D.,Xu, Y.,Goldgur, Y.,De La Cruz, M.J.,de Stanchina, E.,Janes, P.W.,Xu, K.,Dimitrov, D.S.,Nikolov, D.B.; Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells.; Biomed Pharmacother, 161:114494-114494, 2023; PubMed: 36917886; DOI: 10.1016/j.biopha.2023.114494

Experimental method

X-RAY DIFFRACTION (3.8 Å)