7M2G
 
 | | INTERLEUKIN-2 (human) mutant P65K, C125S | | Descriptor: | GLYCEROL, Interleukin-2, SULFATE ION | | Authors: | Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M. | | Deposit date: | 2021-03-16 | | Release date: | 2021-08-04 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Nat Commun, 12, 2021
|
|
7YGI
 | | Crystal structure of p53 DBD domain in complex with azurin | | Descriptor: | Azurin, Cellular tumor antigen p53, PHOSPHATE ION, ... | | Authors: | Jiang, W.X, Zuo, J.Q, Hu, J.J, Chen, X.Q, Ma, L.X, Liu, Z, Xing, Q. | | Deposit date: | 2022-07-11 | | Release date: | 2023-02-08 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Commun Biol, 6, 2023
|
|
7X6O
 | |
7X6L
 | |
2JN7
 | | Northeast Structural Genomics Consortium Target ER411 | | Descriptor: | protein yfjZ | | Authors: | Tian, F, Zhao, L, Jiang, M, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2006-12-28 | | Release date: | 2007-01-09 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of E.Coli hypothetical protein YFJZ
To be Published
|
|
8WPF
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exogenous DNA bearing one abasic site | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
|
|
8WPE
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 (tag-free A22) with exogenous DNA | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
|
|
8WPP
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with endogenous DNA | | Descriptor: | A22R DNA polymerase processivity factor, DNA polymerase, E4R Uracil-DNA glycosylase, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
|
|
8WPK
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exgenous DNA | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
|
|
7CK9
 | | Crystal structure of Doxorubicin loaded human ferritin heavy chain | | Descriptor: | CHLORIDE ION, Ferritin heavy chain, GLYCEROL, ... | | Authors: | Chen, X, Jiang, B, Yan, X, Fan, K. | | Deposit date: | 2020-07-16 | | Release date: | 2021-05-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.602 Å) | | Cite: | A natural drug entry channel in the ferritin nanocage.
Nano Today, 35, 2020
|
|
7DDZ
 | | The Crystal Structure of Human Neuropeptide Y Y2 Receptor with JNJ-31020028 | | Descriptor: | FLAVIN MONONUCLEOTIDE, Human Neuropeptide Y Y2 Receptor fusion protein, ~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide | | Authors: | Tang, T, Han, S, Zhao, Q, Wu, B. | | Deposit date: | 2020-10-30 | | Release date: | 2021-01-27 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for ligand recognition of the neuropeptide Y Y 2 receptor.
Nat Commun, 12, 2021
|
|
7DBI
 | | Crystal structure of the peroxisomal acyl-CoA hydrolase MpaH | | Descriptor: | acyl-CoA hydrolase MpaH' | | Authors: | Li, S.Y, You, C. | | Deposit date: | 2020-10-20 | | Release date: | 2021-04-28 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis.
Febs J., 288, 2021
|
|
7DBL
 | | Acyl-CoA hydrolase MpaH' mutant S139A in complex with MPA | | Descriptor: | MYCOPHENOLIC ACID, acyl-CoA hydrolase MpaH' | | Authors: | Li, S.Y, You, C. | | Deposit date: | 2020-10-20 | | Release date: | 2021-04-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis.
Febs J., 288, 2021
|
|
7BW0
 | | Active human TGR5 complex with a synthetic agonist 23H | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. | | Deposit date: | 2020-04-12 | | Release date: | 2020-09-02 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein.
Signal Transduct Target Ther, 5, 2020
|
|
1QK6
 | | Solution structure of huwentoxin-I by NMR | | Descriptor: | HUWENTOXIN-I | | Authors: | Qu, Y, Liang, S, Ding, J, Liu, X, Zhang, R, Gu, X. | | Deposit date: | 1999-07-10 | | Release date: | 1999-08-20 | | Last modified: | 2019-01-16 | | Method: | SOLUTION NMR | | Cite: | Proton Nuclear Magnetic Resonance Studies on Huwentoxin-I from the Venom of the Spider Selenocosmia Huwena:2.Three-Dimensional Structure in Solution
J.Protein Chem., 16, 1997
|
|
7WKS
 | | Apo state of AtPIN3 | | Descriptor: | Auxin efflux carrier component 3 | | Authors: | Su, N. | | Deposit date: | 2022-01-11 | | Release date: | 2022-08-10 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
|
|
7WKW
 | | NPA bound state of AtPIN3 | | Descriptor: | 2-(naphthalen-1-ylcarbamoyl)benzoic acid, Auxin efflux carrier component 3 | | Authors: | Su, N. | | Deposit date: | 2022-01-11 | | Release date: | 2022-08-10 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.62 Å) | | Cite: | Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
|
|
7Y65
 | | Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | | Descriptor: | C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
|
|
7Y64
 | | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | | Descriptor: | C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
|
|
7Y66
 | | Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein | | Descriptor: | BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
|
|
7XXI
 | | Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi | | Descriptor: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | | Deposit date: | 2022-05-30 | | Release date: | 2023-06-07 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023
|
|
7XXH
 | | Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11 | | Descriptor: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | | Deposit date: | 2022-05-30 | | Release date: | 2023-06-07 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023
|
|
7Y67
 | | Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein | | Descriptor: | C089 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
|
|
7WVY
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | | Descriptor: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | Deposit date: | 2022-02-11 | | Release date: | 2022-04-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
|
|
7WVW
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | | Descriptor: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | Deposit date: | 2022-02-11 | | Release date: | 2022-04-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
|
|
