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5XWY
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BU of 5xwy by Molmil
Electron cryo-microscopy structure of LbuCas13a-crRNA binary complex
Descriptor: A type VI-A CRISPR-Cas RNA-guided RNA ribonuclease, Cas13a, RNA (59-MER)
Authors:Zhang, X, Wang, Y, Ma, J, Liu, L, Li, X, Li, Z, You, L, Wang, J, Wang, M.
Deposit date:2017-06-30
Release date:2017-09-13
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Cell, 170, 2017
5XMI
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BU of 5xmi by Molmil
Cryo-EM Structure of the ATP-bound VPS4 mutant-E233Q hexamer (masked)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Vacuolar protein sorting-associated protein 4
Authors:Sun, S, Li, L, Yang, F, Wang, X, Fan, F, Li, X, Wang, H, Sui, S.
Deposit date:2017-05-15
Release date:2017-08-09
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the ATP-bound Vps4(E233Q) hexamer and its complex with Vta1 at near-atomic resolution
Nat Commun, 8, 2017
2I78
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BU of 2i78 by Molmil
Crystal structure of human dipeptidyl peptidase IV (DPP IV) complexed with ABT-341, a cyclohexene-constrained phenethylamine inhibitor
Descriptor: (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE, Dipeptidyl peptidase IV
Authors:Longenecker, K.L, Pei, Z, Li, X.
Deposit date:2006-08-30
Release date:2007-10-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of Cyclohexene-constrained Phenethylamine ABT-341, a Highly Potent, Selective, Orally Bioavailable, Safe and Potential Next-generation Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
To be Published
8ZYX
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BU of 8zyx by Molmil
Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F6-R54S Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Wang, X, Ge, J, Li, X.
Deposit date:2024-06-18
Release date:2025-07-02
Method:ELECTRON MICROSCOPY (2.33 Å)
Cite:Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F6-R54S Fab
To Be Published
5XWP
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BU of 5xwp by Molmil
Crystal structure of LbuCas13a-crRNA-target RNA ternary complex
Descriptor: RNA (30-MER), RNA (59-MER), Uncharacterized protein
Authors:Liu, L, Li, X, Li, Z, Wang, Y.
Deposit date:2017-06-30
Release date:2017-09-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.086 Å)
Cite:The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Cell, 170, 2017
5DDZ
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BU of 5ddz by Molmil
Crystal structure of the RTA-c10-P2 complex
Descriptor: 60S acidic ribosomal protein P2, Ricin
Authors:Zhu, Y, Fan, X, Wang, C, Niu, L, Li, X, Teng, M.
Deposit date:2015-08-25
Release date:2016-09-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insights into the interaction of the ribosomal P stalk protein P2 with a type II ribosome-inactivating protein ricin
Sci Rep, 6, 2016
9MS8
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BU of 9ms8 by Molmil
PTCH1 in complex with Fab6H3
Descriptor: 6H3 Fab heavy chain, 6H3 Fab light chain, Protein patched homolog 1
Authors:Hu, Q, Qi, X, Li, X.
Deposit date:2025-01-09
Release date:2025-04-02
Last modified:2025-04-16
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Inhibiting hedgehog signal by a patched-1 antibody.
Cell Discov, 11, 2025
5TJB
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BU of 5tjb by Molmil
I-II linker of TRPML1 channel at pH 4.5
Descriptor: Mucolipin-1
Authors:Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J.
Deposit date:2016-10-04
Release date:2017-01-25
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
5TJA
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BU of 5tja by Molmil
I-II linker of TRPML1 channel at pH 6
Descriptor: Mucolipin-1
Authors:Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J.
Deposit date:2016-10-04
Release date:2017-01-25
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
5TJC
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BU of 5tjc by Molmil
I-II linker of TRPML1 channel at pH 7.5
Descriptor: Mucolipin-1
Authors:Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J.
Deposit date:2016-10-04
Release date:2017-01-25
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
6WEL
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BU of 6wel by Molmil
Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs
Descriptor: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ...
Authors:Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
4TVV
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BU of 4tvv by Molmil
Crystal structure of LppA from Legionella pneumophila
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Weber, S, Stirnimann, C, Wieser, M, Meier, R, Engelhardt, S, Li, X, Capitani, G, Kammerer, R, Hilbi, H.
Deposit date:2014-06-28
Release date:2014-11-05
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Type IV Translocated Legionella Cysteine Phytase Counteracts Intracellular Growth Restriction by Phytate.
J.Biol.Chem., 289, 2014
9KOD
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BU of 9kod by Molmil
Neuraminidase of A/dairy cow/Minnesota/24_016288-003/2024 (dcMN24 N1) in complex with CAV-F6 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CAV-F6 heavy chain, ...
Authors:Wang, X, Ge, J, Li, X.
Deposit date:2024-11-20
Release date:2025-07-02
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Neuraminidase of A/dairy cow/Minnesota/24_016288-003/2024 (dcMN24 N1) in complex with CAV-F6 Fab
To Be Published
7F7I
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BU of 7f7i by Molmil
Stapled Peptide Inhibitor in complex with PSD95 GK domain
Descriptor: ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2, Disks large homolog 4
Authors:Shang, Y, Huang, X, Li, X, Zhang, M.
Deposit date:2021-06-29
Release date:2022-04-06
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
6WEJ
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BU of 6wej by Molmil
Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs
Descriptor: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ...
Authors:Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6WEK
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BU of 6wek by Molmil
Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs
Descriptor: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ...
Authors:Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6LH8
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BU of 6lh8 by Molmil
Structure of aerolysin-like protein (Bombina maxima)
Descriptor: aerolysin-like protein
Authors:Bian, X.L, Wang, Q.Q, Li, X, Teng, M.Q, Zhang, Y.
Deposit date:2019-12-07
Release date:2020-06-10
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.729 Å)
Cite:A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions.
J.Biol.Chem., 295, 2020
5D68
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BU of 5d68 by Molmil
Crystal structure of KRIT1 ARD-FERM
Descriptor: Krev interaction trapped protein 1
Authors:Zhang, R, Li, X, Boggon, T.J.
Deposit date:2015-08-11
Release date:2015-10-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface.
J.Struct.Biol., 192, 2015
6LHZ
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BU of 6lhz by Molmil
Structure of aerolysin-like protein (Bombina maxima)
Descriptor: aerolysin-like protein
Authors:Bian, X.L, Wang, Q.Q, Li, X, Teng, M.Q, Zhang, Y.
Deposit date:2019-12-10
Release date:2020-06-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions.
J.Biol.Chem., 295, 2020
5D1I
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BU of 5d1i by Molmil
Structure of Cyclic nucleotide-binding-like protein from Brucella abortus bv. 1 str. 9-941
Descriptor: Cyclic nucleotide-binding protein
Authors:He, Z, Dong, J, Li, X, Gao, Y.
Deposit date:2015-08-04
Release date:2015-09-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of cyclic nucleotide-binding-like protein from Brucella abortus
Biochem.Biophys.Res.Commun., 468, 2015
4CEY
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BU of 4cey by Molmil
Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor NLD
Descriptor: 1-(2-aminopyridin-4-yl)-3-[(3S)-5-{4-[(E)-(ethoxyimino)methyl]phenoxy}-3-methylpentyl]imidazolidin-2-one, SODIUM ION, VP1, ...
Authors:De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I.
Deposit date:2013-11-12
Release date:2014-02-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
4CDX
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BU of 4cdx by Molmil
Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12
Descriptor: 1-(5-((3'-METHYL-[1,1'-BIPHENYL]-4-YL)OXY)PENTYL)-3-(, SODIUM ION, VP1, ...
Authors:De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I.
Deposit date:2013-11-07
Release date:2014-02-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules.
Nat.Struct.Mol.Biol., 21, 2014
4CDW
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BU of 4cdw by Molmil
Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP4
Descriptor: 1-[(3S)-5-(4-iodanylphenoxy)-3-methyl-pentyl]-3-pyridin-4-yl-imidazolidin-2-one, SODIUM ION, VP1, ...
Authors:De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I.
Deposit date:2013-11-06
Release date:2014-02-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
4CDQ
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BU of 4cdq by Molmil
Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP2
Descriptor: 4-((5-(2-oxo-3-(pyridin-4-yl)imidazolidin-1-yl)pentyl)oxy)benzaldehyde O-ethyl oxime, SODIUM ION, VP1, ...
Authors:DeColibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I.
Deposit date:2013-11-05
Release date:2014-02-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
4CEW
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BU of 4cew by Molmil
Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor ALD
Descriptor: 4-[3-[(3s)-5-[4-[(e)-ethoxyiminomethyl]phenoxy]-3-methyl-pentyl]-2-oxidanylidene-imidazolidin-1-yl]pyridine-2-carboxamide, VP1, VP2, ...
Authors:De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I.
Deposit date:2013-11-12
Release date:2014-02-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules.
Nat.Struct.Mol.Biol., 21, 2014

238582

数据于2025-07-09公开中

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