7F7I

Stapled Peptide Inhibitor in complex with PSD95 GK domain

Summary for 7F7I

• Entry DOI: 10.2210/pdb7f7i/pdb
• Related: 7F7G
• Descriptor: Disks large homolog 4, ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2 (3 entities in total)
• Functional Keywords: maguk stapled peptide entropy gk domain, peptide binding protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 12
• Total formula weight: 151292.66

Authors

Shang, Y.,Huang, X.,Li, X.,Zhang, M. (deposition date: 2021-06-29, release date: 2022-04-06, Last modification date: 2023-11-29)

• Primary citation: Unarta, I.C.,Xu, J.,Shang, Y.,Cheung, C.H.P.,Zhu, R.,Chen, X.,Cao, S.,Cheung, P.P.,Bierer, D.,Zhang, M.,Huang, X.,Li, X.; Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.; Rsc Chem Biol, 2:1274-1284, 2021; PubMed: 34458841; DOI: 10.1039/d1cb00087j

Experimental method

X-RAY DIFFRACTION (2.595 Å)