7SF7
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![BU of 7sf7 by Molmil](/molmil-images/mine/7sf7) | LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer | Descriptor: | G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Barros-Alvarez, X, Panova, O, Skiniotis, G. | Deposit date: | 2021-10-03 | Release date: | 2022-04-27 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The tethered peptide activation mechanism of adhesion GPCRs. Nature, 604, 2022
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4QQN
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![BU of 4qqn by Molmil](/molmil-images/mine/4qqn) | Protein arginine methyltransferase 3 in complex with compound MTV044246 | Descriptor: | 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, CHLORIDE ION, GLYCEROL, ... | Authors: | Dong, A, Dobrovetsky, E, Tempel, W, He, H, Zhao, K, Smil, D, Landon, M, Luo, X, Chen, Z, Dai, M, Yu, Z, Lin, Y, Zhang, H, Zhao, K, Schapira, M, Brown, P.J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Structural Genomics Consortium (SGC) | Deposit date: | 2014-06-27 | Release date: | 2014-09-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J. Med. Chem., 61, 2018
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6LR2
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![BU of 6lr2 by Molmil](/molmil-images/mine/6lr2) | |
4HUQ
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![BU of 4huq by Molmil](/molmil-images/mine/4huq) | Crystal Structure of a transporter | Descriptor: | Energy-coupling factor transporter ATP-binding protein EcfA 1, Energy-coupling factor transporter ATP-binding protein EcfA 2, Energy-coupling factor transporter transmembrane protein EcfT, ... | Authors: | Zhang, P, Xu, K, Zhang, M, Zhao, Q, Yu, F. | Deposit date: | 2012-11-03 | Release date: | 2013-04-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.998 Å) | Cite: | Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature, 497, 2013
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6P66
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![BU of 6p66 by Molmil](/molmil-images/mine/6p66) | |
7UL2
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![BU of 7ul2 by Molmil](/molmil-images/mine/7ul2) | CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6 | Descriptor: | 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Nanobody 6, Neurotensin receptor 1, ... | Authors: | Robertson, M.J, Skiniotis, G. | Deposit date: | 2022-04-03 | Release date: | 2022-06-29 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structure determination of inactive-state GPCRs with a universal nanobody. Nat.Struct.Mol.Biol., 29, 2022
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7UL4
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![BU of 7ul4 by Molmil](/molmil-images/mine/7ul4) | CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6 | Descriptor: | Megabody 6, Mu-type opioid receptor, N-[(2S)-2-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine | Authors: | Robertson, M.J, Skiniotis, G. | Deposit date: | 2022-04-03 | Release date: | 2022-06-29 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure determination of inactive-state GPCRs with a universal nanobody. Nat.Struct.Mol.Biol., 29, 2022
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7UL5
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7UL3
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![BU of 7ul3 by Molmil](/molmil-images/mine/7ul3) | CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab | Descriptor: | Histamine H2 receptor, NabFab HC, NabFab LC, ... | Authors: | Robertson, M.J, Skiniotis, G. | Deposit date: | 2022-04-03 | Release date: | 2022-06-29 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure determination of inactive-state GPCRs with a universal nanobody. Nat.Struct.Mol.Biol., 29, 2022
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7V2Y
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![BU of 7v2y by Molmil](/molmil-images/mine/7v2y) | cryo-EM structure of yeast THO complex with Sub2 | Descriptor: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-10 | Release date: | 2022-07-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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7V2W
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![BU of 7v2w by Molmil](/molmil-images/mine/7v2w) | protomer structure from the dimer of yeast THO complex | Descriptor: | Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ... | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-10 | Release date: | 2022-07-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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4Z8M
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![BU of 4z8m by Molmil](/molmil-images/mine/4z8m) | Crystal structure of the MAVS-TRAF6 complex | Descriptor: | Peptide from Mitochondrial antiviral-signaling protein, TNF receptor-associated factor 6 | Authors: | Shi, Z.B, Zhou, Z. | Deposit date: | 2015-04-09 | Release date: | 2015-09-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling J.Biol.Chem., 290, 2015
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2RRB
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![BU of 2rrb by Molmil](/molmil-images/mine/2rrb) | Refinement of RNA binding domain in human Tra2 beta protein | Descriptor: | cDNA FLJ40872 fis, clone TUTER2000283, highly similar to Homo sapiens transformer-2-beta (SFRS10) gene | Authors: | Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2010-06-17 | Release date: | 2011-04-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM. Nucleic Acids Res., 39, 2011
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3Q0Z
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![BU of 3q0z by Molmil](/molmil-images/mine/3q0z) | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid | Descriptor: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, RNA-directed RNA polymerase, SULFATE ION | Authors: | Sheriff, S. | Deposit date: | 2010-12-16 | Release date: | 2011-04-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus. Bioorg.Med.Chem.Lett., 21, 2011
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1WWN
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![BU of 1wwn by Molmil](/molmil-images/mine/1wwn) | NMR Solution Structure of BmK-betaIT, an Excitatory Scorpion Toxin from Buthus martensi Karsch | Descriptor: | Excitatory insect selective toxin 1 | Authors: | Wu, H, Tong, X, Chen, X, Zhang, Q, Zheng, X, Zhang, N, Wu, G. | Deposit date: | 2005-01-10 | Release date: | 2006-01-17 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position Biochem.Biophys.Res.Commun., 349, 2006
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4LN0
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![BU of 4ln0 by Molmil](/molmil-images/mine/4ln0) | Crystal structure of the VGLL4-TEAD4 complex | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Transcription cofactor vestigial-like protein 4, ... | Authors: | Wang, H, Shi, Z, Zhou, Z. | Deposit date: | 2013-07-11 | Release date: | 2014-02-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.896 Å) | Cite: | A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell, 25, 2014
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4M5F
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![BU of 4m5f by Molmil](/molmil-images/mine/4m5f) | complex structure of Tse3-Tsi3 | Descriptor: | CALCIUM ION, PHOSPHATE ION, Uncharacterized protein | Authors: | Gu, L.C. | Deposit date: | 2013-08-08 | Release date: | 2014-04-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol., 92, 2014
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2E0H
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![BU of 2e0h by Molmil](/molmil-images/mine/2e0h) | |
4N7S
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![BU of 4n7s by Molmil](/molmil-images/mine/4n7s) | Crystal structure of Tse3-Tsi3 complex with Zinc ion | Descriptor: | ACETATE ION, CALCIUM ION, CHLORIDE ION, ... | Authors: | Shang, G.J. | Deposit date: | 2013-10-16 | Release date: | 2014-04-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol., 92, 2014
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4N88
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![BU of 4n88 by Molmil](/molmil-images/mine/4n88) | Crystal structure of Tse3-Tsi3 complex with calcium ion | Descriptor: | CALCIUM ION, Uncharacterized protein | Authors: | Shang, G.J. | Deposit date: | 2013-10-17 | Release date: | 2014-04-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol., 92, 2014
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4M5E
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![BU of 4m5e by Molmil](/molmil-images/mine/4m5e) | Tse3 structure | Descriptor: | CADMIUM ION, CALCIUM ION, GLYCEROL, ... | Authors: | Qian, Y. | Deposit date: | 2013-08-08 | Release date: | 2014-04-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol., 92, 2014
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4N80
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![BU of 4n80 by Molmil](/molmil-images/mine/4n80) | Crystal structure of Tse3-Tsi3 complex | Descriptor: | CALCIUM ION, Uncharacterized protein, ZINC ION | Authors: | Shang, G.J. | Deposit date: | 2013-10-16 | Release date: | 2014-04-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol., 92, 2014
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4N6J
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![BU of 4n6j by Molmil](/molmil-images/mine/4n6j) | Crystal structure of human Striatin-3 coiled coil domain | Descriptor: | Striatin-3 | Authors: | Chen, C, Shi, Z, Zhou, Z. | Deposit date: | 2013-10-13 | Release date: | 2014-02-26 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. J.Biol.Chem., 289, 2014
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5X3X
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![BU of 5x3x by Molmil](/molmil-images/mine/5x3x) | 2.8A resolution structure of a cobalt energy-coupling factor transporter-CbiMQO | Descriptor: | Cobalt ABC transporter ATP-binding protein, Cobalt transport protein CbiM, Uncharacterized protein CbiQ | Authors: | Bao, Z, Qi, X, Wang, J, Zhang, P. | Deposit date: | 2017-02-09 | Release date: | 2017-04-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.788 Å) | Cite: | Structure and mechanism of a group-I cobalt energy coupling factor transporter Cell Res., 27, 2017
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5W77
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![BU of 5w77 by Molmil](/molmil-images/mine/5w77) | Solution structure of the MYC G-quadruplex bound to small molecule DC-34 | Descriptor: | 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-benzofuran-3-carboxamide, DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION | Authors: | Chen, X, Walters, K.J. | Deposit date: | 2017-06-19 | Release date: | 2018-10-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nat Commun, 9, 2018
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