5W77
Solution structure of the MYC G-quadruplex bound to small molecule DC-34
Summary for 5W77
Entry DOI | 10.2210/pdb5w77/pdb |
NMR Information | BMRB: 27144 |
Descriptor | DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION, 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-benzofuran-3-carboxamide (3 entities in total) |
Functional Keywords | c-myc promoter dna-inhibitor complex, c-myc promoter g-quadruplex, dna, dna-inhibitor complex, dna/inhibitor |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 7979.63 |
Authors | Chen, X.,Walters, K.J. (deposition date: 2017-06-19, release date: 2018-10-24, Last modification date: 2024-05-15) |
Primary citation | Calabrese, D.R.,Chen, X.,Leon, E.C.,Gaikwad, S.M.,Phyo, Z.,Hewitt, W.M.,Alden, S.,Hilimire, T.A.,He, F.,Michalowski, A.M.,Simmons, J.K.,Saunders, L.B.,Zhang, S.,Connors, D.,Walters, K.J.,Mock, B.A.,Schneekloth Jr., J.S. Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nat Commun, 9:4229-4229, 2018 Cited by PubMed: 30315240DOI: 10.1038/s41467-018-06315-w PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report