5W77

Solution structure of the MYC G-quadruplex bound to small molecule DC-34

Spectrometer

Experimental method: SOLUTION NMR

Spectrometer ID	Spectrometer maker	Spectrometer model	Spectrometer type	Spectrometer field strength
1	Bruker	AVANCE		850
2	Bruker	AVANCE		800
3	Bruker	AVANCE		700

Experiment

experiment id	conditions id	solution id	Experiment type
1	1	1	2D 1H-1H NOESY
10	1	4	3D 13C half-filtered NOESY
11	1	5	2D 1H-1H TOCSY
12	1	5	2D 1H-1H NOESY
13	1	5	2D 1H-1H COSY
14	1	5	2D 1H-13C HSQC
15	1	5	2D 1H-13C HMBC
16	1	6	1D 1H
2	1	2	2D 1H-1H NOESY
3	1	3	2D 1H-1H NOESY
4	1	2	2D 1H-1H NOESY
5	1	3	2D 1H-1H NOESY
6	1	2	2D 1H-1H TOCSY
7	1	2	2D 1H-1H COSY
8	1	3	2D 1H-1H TOCSY
9	1	3	2D 1H-1H COSY

NMR Sample

conditions id	NMR sample pH	NMR sample pressure	NMR sample temperature
1	6.4	1	298.2

Conformers

Conformers Calculated Total Number	100
Conformers Submitted Total Number	15