6LBI
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6OT1
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6OSY
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8HN9
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![BU of 8hn9 by Molmil](/molmil-images/mine/8hn9) | Human SIRT3 Recognizing CCNE2K348la peptide | Descriptor: | CCNE2 peptide, IMIDAZOLE, NAD-dependent protein deacetylase sirtuin-3, ... | Authors: | Wang, Y, Ding, W. | Deposit date: | 2022-12-07 | Release date: | 2023-05-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth. Embo Rep., 24, 2023
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8HBM
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5H9D
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![BU of 5h9d by Molmil](/molmil-images/mine/5h9d) | Crystal structure of Heptaprenyl Diphosphate Synthase from Staphylococcus aureus | Descriptor: | C-terminal peptide from Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 family protein, Farnesyl pyrophosphate synthetase, Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 family protein, ... | Authors: | Wei, H.L, Liu, W.D, Zheng, Y.Y, Ko, T.P, Chen, C.C, Guo, R.T. | Deposit date: | 2015-12-28 | Release date: | 2016-12-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase ChemMedChem, 11, 2016
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7XUZ
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![BU of 7xuz by Molmil](/molmil-images/mine/7xuz) | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | Descriptor: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | Authors: | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | Deposit date: | 2022-05-20 | Release date: | 2023-11-29 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (3.591 Å) | Cite: | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Nucleic Acids Res., 52, 2024
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7V29
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![BU of 7v29 by Molmil](/molmil-images/mine/7v29) | Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor | Descriptor: | Fibroblast growth factor receptor 4, N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide, SULFATE ION | Authors: | Chen, X.J, Jiang, L.Y, Dai, S.Y, Qu, L.Z, Chen, Y.H. | Deposit date: | 2021-08-07 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.983 Å) | Cite: | Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem, 5, 2022
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7D42
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6L6L
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![BU of 6l6l by Molmil](/molmil-images/mine/6l6l) | Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements | Descriptor: | DNA (5'-D(*AP*AP*AP*GP*GP*TP*CP*AP*AP*AP*CP*TP*GP*TP*GP*AP*CP*CP*TP*AP*T)-3'), DNA (5'-D(P*TP*AP*TP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*TP*TP*GP*AP*CP*CP*TP*T)-3'), Nuclear receptor related 1, ... | Authors: | Jiang, L, Chen, Y. | Deposit date: | 2019-10-29 | Release date: | 2019-11-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.781 Å) | Cite: | Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements. J.Biol.Chem., 294, 2019
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6XOS
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6XOU
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6XOV
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6XOT
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6L6Q
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6LC1
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7W1K
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![BU of 7w1k by Molmil](/molmil-images/mine/7w1k) | Crystal structure of carboxylesterase from Thermobifida fusca | Descriptor: | Carboxylesterase | Authors: | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | Deposit date: | 2021-11-19 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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7W1I
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![BU of 7w1i by Molmil](/molmil-images/mine/7w1i) | Crystal structure of carboxylesterase mutant from Thermobifida fusca with C8X and C9C | Descriptor: | 4-(2-hydroxyethyloxycarbonyl)benzoic acid, Carboxylesterase, bis(2-hydroxyethyl) benzene-1,4-dicarboxylate | Authors: | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | Deposit date: | 2021-11-19 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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7W1J
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![BU of 7w1j by Molmil](/molmil-images/mine/7w1j) | Crystal structure of carboxylesterase from Thermobifida fusca with J1K | Descriptor: | 4-(2-hydroxyethylcarbamoyl)benzoic acid, Carboxylesterase | Authors: | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | Deposit date: | 2021-11-19 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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7W1L
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![BU of 7w1l by Molmil](/molmil-images/mine/7w1l) | Crystal structure of carboxylesterase mutant from Thermobifida fusca with C8X | Descriptor: | Carboxylesterase, bis(2-hydroxyethyl) benzene-1,4-dicarboxylate | Authors: | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | Deposit date: | 2021-11-19 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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6VAB
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![BU of 6vab by Molmil](/molmil-images/mine/6vab) | Mouse retromer sub-structure: VPS35/VPS35 flat dimer | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | Authors: | Kendall, A.K, Jackson, L.P. | Deposit date: | 2019-12-17 | Release date: | 2020-02-19 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes. Structure, 28, 2020
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6VAC
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![BU of 6vac by Molmil](/molmil-images/mine/6vac) | Mouse retromer (VPS26/VPS35/VPS29) heterotrimer | Descriptor: | Vacuolar protein sorting-associated protein 26A, Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | Authors: | Kendall, A.K, Jackson, L.P. | Deposit date: | 2019-12-17 | Release date: | 2020-02-19 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes. Structure, 28, 2020
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6GY1
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![BU of 6gy1 by Molmil](/molmil-images/mine/6gy1) | rat COMT in complex with inhibitor | Descriptor: | 7-fluoranyl-5-(4-methylphenyl)sulfonyl-quinolin-8-ol, Catechol O-methyltransferase, DIMETHYL SULFOXIDE, ... | Authors: | Schulze, M.-S. | Deposit date: | 2018-06-27 | Release date: | 2018-10-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase. J. Med. Chem., 61, 2018
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7RZH
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![BU of 7rzh by Molmil](/molmil-images/mine/7rzh) | Insulin Degrading Enzyme O/O | Descriptor: | Cysteine-free Insulin-degrading enzyme | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | Deposit date: | 2021-08-27 | Release date: | 2022-08-31 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZI
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![BU of 7rzi by Molmil](/molmil-images/mine/7rzi) | Insulin Degrading Enzyme pC/pC | Descriptor: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | Deposit date: | 2021-08-27 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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