6GY1

rat COMT in complex with inhibitor

Summary for 6GY1

Entry DOI	10.2210/pdb6gy1/pdb
Descriptor	Catechol O-methyltransferase, MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total)
Functional Keywords	magnesium ion binding, o-methyltransferase activity, neurotransmitter catabolic process, transferase
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	25720.72
Authors	Schulze, M.-S. (deposition date: 2018-06-27, release date: 2018-10-10, Last modification date: 2024-01-17)
Primary citation	Buchler, I.,Akuma, D.,Au, V.,Carr, G.,de Leon, P.,DePasquale, M.,Ernst, G.,Huang, Y.,Kimos, M.,Kolobova, A.,Poslusney, M.,Wei, H.,Swinnen, D.,Montel, F.,Moureau, F.,Jigorel, E.,Schulze, M.E.D.,Wood, M.,Barrow, J.C. Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase. J. Med. Chem., 61:9647-9665, 2018 Cited by PubMed: 30272964 DOI: 10.1021/acs.jmedchem.8b01126 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation