7EH1
 
 | | Thermus thermophilus transcription initiation complex containing a template-strand purine at position TSS-2, GpG RNA primer, and CMPcPP | | Descriptor: | 1,4-BUTANEDIOL, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), ... | | Authors: | Li, L, Zhang, Y. | | Deposit date: | 2021-03-27 | | Release date: | 2021-07-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli .
Proc.Natl.Acad.Sci.USA, 118, 2021
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7CYQ
 | | Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... | | Authors: | Yan, L, Ge, J, Zheng, L, Zhang, Y, Gao, Y, Wang, T, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | Deposit date: | 2020-09-04 | | Release date: | 2020-12-09 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.
Cell, 184, 2021
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7C1H
 | | Crystal structure of the starter condensation domain of rhizomide synthetase RzmA | | Descriptor: | Non-ribosomal peptide synthetase modules | | Authors: | Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X. | | Deposit date: | 2020-05-04 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.
Nat Commun, 12, 2021
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7C1R
 | | Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant H140A/R148A in complex with C8-CoA | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Non-ribosomal peptide synthetase modules, OCTANOYL-COENZYME A | | Authors: | Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X. | | Deposit date: | 2020-05-05 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.
Nat Commun, 12, 2021
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7C1P
 | | Crystal structure of the starter condensation domain of the rhizomide synthetase RzmA mutant H140V, R148A | | Descriptor: | Non-ribosomal peptide synthetase modules | | Authors: | Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D. | | Deposit date: | 2020-05-05 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.
Nat Commun, 12, 2021
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7C1S
 | | Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant H140A/R148A in complex with C8-CoA and Leu-SNAC | | Descriptor: | Non-ribosomal peptide synthetase modules, OCTANOYL-COENZYME A, S-(2-acetamidoethyl) (2S)-2-azanyl-4-methyl-pentanethioate | | Authors: | Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X. | | Deposit date: | 2020-05-05 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.586 Å) | | Cite: | Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.
Nat Commun, 12, 2021
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7C7S
 | | Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state. | | Descriptor: | (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ... | | Authors: | Mao, C, Shen, C, Li, C, Shen, D, Xu, C, Zhang, S, Zhou, R, Shen, Q, Chen, L, Jiang, Z, Liu, J, Zhang, Y. | | Deposit date: | 2020-05-26 | | Release date: | 2020-07-01 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structures of inactive and active GABABreceptor.
Cell Res., 30, 2020
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7CMV
 | | Dopamine Receptor D3R-Gi-PD128907 complex | | Descriptor: | (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | | Deposit date: | 2020-07-29 | | Release date: | 2021-03-10 | | Last modified: | 2021-04-07 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structures of the human dopamine D3 receptor-G i complexes.
Mol.Cell, 81, 2021
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7CMU
 | | Dopamine Receptor D3R-Gi-Pramipexole complex | | Descriptor: | (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | | Deposit date: | 2020-07-29 | | Release date: | 2021-03-10 | | Last modified: | 2021-04-07 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of the human dopamine D3 receptor-G i complexes.
Mol.Cell, 81, 2021
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7E7L
 | | The crystal structure of arylacetate decarboxylase from Olsenella scatoligenes. | | Descriptor: | 4-HYDROXYPHENYLACETATE, Hydroxyphenylacetic acid decarboxylase | | Authors: | Lu, Q, Duan, Y, Zhang, Y, Yuchi, Z. | | Deposit date: | 2021-02-26 | | Release date: | 2021-07-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.53 Å) | | Cite: | The Glycyl Radical Enzyme Arylacetate Decarboxylase from Olsenella scatoligenes
Acs Catalysis, 11, 2021
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7XNG
 | | Crystal structure of CBP bromodomain liganded with Y08092(31g) | | Descriptor: | 3-[(1-ethanoylindol-3-yl)carbonylamino]-5-[[(2S)-oxan-2-yl]oxymethyl]benzoic acid, CREB-binding protein, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Xiang, Q, Zhang, Y, Wang, C, Song, M, Xu, Y. | | Deposit date: | 2022-04-28 | | Release date: | 2022-06-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal structure of CBP bromodomain liganded with Y08092(31g)
To Be Published
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7XM7
 | | Crystal Structure of the CBP in complex with the Y08188 | | Descriptor: | 1,2-ETHANEDIOL, 3-ethanoyl-~{N}-[2-fluoranyl-3-(1-methylpyrazol-4-yl)phenyl]-7-methoxy-indolizine-1-carboxamide, CREB-binding protein, ... | | Authors: | Xiang, Q, Zhang, Y, Wang, C, Song, M, Xu, Y. | | Deposit date: | 2022-04-25 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as potent and selective CBP bromodomain inhibitors
To Be Published
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7CXN
 | | Architecture of a SARS-CoV-2 mini replication and transcription complex | | Descriptor: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | Deposit date: | 2020-09-02 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
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7CXM
 | | Architecture of a SARS-CoV-2 mini replication and transcription complex | | Descriptor: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | Deposit date: | 2020-09-02 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
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7XZR
 | | Crystal structure of TNIK-AMPPNP-thiopeptide TP15 complex | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... | | Authors: | Hamada, K, Vinogradov, A.A, Zhang, Y, Chang, J.S, Nishimura, H, Goto, Y, Onaka, H, Suga, H, Ogata, K, Sengoku, T. | | Deposit date: | 2022-06-03 | | Release date: | 2022-10-26 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.
J.Am.Chem.Soc., 144, 2022
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7XZQ
 | | Crystal structure of TNIK-thiopeptide TP1 complex | | Descriptor: | 1,4-BUTANEDIOL, TRAF2 and NCK-interacting protein kinase, thiopeptide TP1 | | Authors: | Hamada, K, Vinogradov, A.A, Zhang, Y, Chang, J.S, Nishimura, H, Goto, Y, Onaka, H, Suga, H, Ogata, K, Sengoku, T. | | Deposit date: | 2022-06-03 | | Release date: | 2022-10-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.
J.Am.Chem.Soc., 144, 2022
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7YE1
 | | The cryo-EM structure of C. crescentus GcrA-TACup | | Descriptor: | Cell cycle regulatory protein GcrA, DNA (57-MER)-non template, DNA (57-MER)-template, ... | | Authors: | Wu, X.X, Zhang, Y. | | Deposit date: | 2022-07-05 | | Release date: | 2023-01-18 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structures of Caulobacter crescentus transcription activation complex with an essential cell cycle regulator GcrA
Nucleic Acids Res., 2023
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7YE2
 | | The cryo-EM structure of C. crescentus GcrA-TACdown | | Descriptor: | Cell cycle regulatory protein GcrA, DNA (90-MER)-non template, DNA (90-MER)-template, ... | | Authors: | Wu, X.X, Zhang, Y. | | Deposit date: | 2022-07-05 | | Release date: | 2023-01-18 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structures of Caulobacter crescentus transcription activation complex with an essential cell cycle regulator GcrA
Nucleic Acids Res., 2023
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7CKQ
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7C72
 | | Structure of a mycobacterium tuberculosis puromycin-hydrolyzing peptidase | | Descriptor: | D-MALATE, GLYCEROL, Prolyl oligopeptidase | | Authors: | Ruiz-Carrillo, D, Zhao, Y.H, Feng, Q, Zhou, X, Zhang, Y, Jiang, J, Lukman, M. | | Deposit date: | 2020-05-22 | | Release date: | 2021-03-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.00004458 Å) | | Cite: | Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity.
Proteins, 89, 2021
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7C17
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7F65
 | | Bacetrial Cocaine Esterase with mutations T172R/G173Q/V116K/S117A/A51L, bound to benzoic acid | | Descriptor: | BENZOIC ACID, Cocaine esterase, SULFATE ION | | Authors: | Ouyang, P.F, Zhang, Y, Tong, J. | | Deposit date: | 2021-06-24 | | Release date: | 2021-09-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | Computational Design and Crystal Structure of a Highly Efficient Benzoylecgonine Hydrolase.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7EGS
 | | The crystal structure of lobe domain of E. coli RNA polymerase complexed with the C-terminal domain of UvrD | | Descriptor: | DNA helicase II, DNA-directed RNA polymerase subunit beta, GLYCEROL | | Authors: | Zheng, F, Shen, L, Li, L, Zhang, Y. | | Deposit date: | 2021-03-26 | | Release date: | 2022-04-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crucial role and mechanism of transcription-coupled DNA repair in bacteria.
Nature, 604, 2022
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7XRD
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7DIE
 | | Crystal structure of M. penetrans Ferritin | | Descriptor: | FE (III) ION, Ferritin | | Authors: | Wang, w.m, Zhang, y, Wang, h.f. | | Deposit date: | 2020-11-19 | | Release date: | 2021-05-26 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Ferritin with Atypical Ferroxidase Centers Takes B-Channels as the Pathway for Fe 2+ Uptake from Mycoplasma .
Inorg.Chem., 60, 2021
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