7DIE

Crystal structure of M. penetrans Ferritin

Summary for 7DIE

• Entry DOI: 10.2210/pdb7die/pdb
• Descriptor: Ferritin, FE (III) ION (3 entities in total)
• Functional Keywords: ferritin, iron uptake, iron release., metal binding protein
• Biological source: Mycoplasma penetrans (strain HF-2)
• Total number of polymer chains: 6
• Total formula weight: 125991.54

Authors

Wang, w.m.,Zhang, y.,Wang, h.f. (deposition date: 2020-11-19, release date: 2021-05-26, Last modification date: 2024-03-27)

Primary citation

Wang, W.,Zhang, Y.,Zhao, G.,Wang, H.
Ferritin with Atypical Ferroxidase Centers Takes B-Channels as the Pathway for Fe 2+ Uptake from Mycoplasma .
Inorg.Chem., 60:7207-7216, 2021

PubMed Abstract: Here, we present a 1.9 Å resolution crystal structure of ferritin, which reveals that its ferroxidase center is located on the inner surface of ferritin but not buried within the four-helix of each subunit. Such a ferroxidase center exhibits a lower iron oxidation activity as compared to the reported ferritin. More importantly, we found that Fe enters into the center via the rarely reported B-channels rather than the normal 3- or 4-fold channels. All these findings may provide the structural bases to explore the new iron oxidation mechanism adopted by this special ferritin, which is beneficial for understanding the relationship between the structure and function of ferritin.

PubMed: 33852289
DOI: 10.1021/acs.inorgchem.1c00265

Experimental method

X-RAY DIFFRACTION (1.9 Å)