7XZQ

Crystal structure of TNIK-thiopeptide TP1 complex

Summary for 7XZQ

Entry DOI	10.2210/pdb7xzq/pdb
Related PRD ID	PRD_002379
Descriptor	TRAF2 and NCK-interacting protein kinase, thiopeptide TP1, 1,4-BUTANEDIOL, ... (4 entities in total)
Functional Keywords	ripp, thiopeptide, kinase inhibition, complex, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	37344.85
Authors	Hamada, K.,Vinogradov, A.A.,Zhang, Y.,Chang, J.S.,Nishimura, H.,Goto, Y.,Onaka, H.,Suga, H.,Ogata, K.,Sengoku, T. (deposition date: 2022-06-03, release date: 2022-10-26, Last modification date: 2023-11-29)
Primary citation	Vinogradov, A.A.,Zhang, Y.,Hamada, K.,Chang, J.S.,Okada, C.,Nishimura, H.,Terasaka, N.,Goto, Y.,Ogata, K.,Sengoku, T.,Onaka, H.,Suga, H. De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors. J.Am.Chem.Soc., 144:20332-20341, 2022 Cited by PubMed: 36282922 DOI: 10.1021/jacs.2c07937 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation