7XZQ
Crystal structure of TNIK-thiopeptide TP1 complex
Summary for 7XZQ
Entry DOI | 10.2210/pdb7xzq/pdb |
Related PRD ID | PRD_002379 |
Descriptor | TRAF2 and NCK-interacting protein kinase, thiopeptide TP1, 1,4-BUTANEDIOL, ... (4 entities in total) |
Functional Keywords | ripp, thiopeptide, kinase inhibition, complex, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 37344.85 |
Authors | Hamada, K.,Vinogradov, A.A.,Zhang, Y.,Chang, J.S.,Nishimura, H.,Goto, Y.,Onaka, H.,Suga, H.,Ogata, K.,Sengoku, T. (deposition date: 2022-06-03, release date: 2022-10-26, Last modification date: 2023-11-29) |
Primary citation | Vinogradov, A.A.,Zhang, Y.,Hamada, K.,Chang, J.S.,Okada, C.,Nishimura, H.,Terasaka, N.,Goto, Y.,Ogata, K.,Sengoku, T.,Onaka, H.,Suga, H. De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors. J.Am.Chem.Soc., 144:20332-20341, 2022 Cited by PubMed: 36282922DOI: 10.1021/jacs.2c07937 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
Download full validation report