8ZBZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8zbz by Molmil](/molmil-images/mine/8zbz) | SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of D1F6 Fab, ... | Authors: | Liu, B, Gao, X, Li, Z, Chen, Q, He, J, Xiong, X. | Deposit date: | 2024-04-28 | Release date: | 2024-05-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.71 Å) | Cite: | An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike. Cell Rep, 43, 2024
|
|
8ZBY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8zby by Molmil](/molmil-images/mine/8zby) | SARS-CoV-2 Omicron BA.1 spike trimer (x2-4P) in complex with 3 D1F6 Fabs (0 RBD up) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of D1F6 Fab, ... | Authors: | Liu, B, Gao, X, Li, Z, Chen, Q, He, J, Xiong, X. | Deposit date: | 2024-04-28 | Release date: | 2024-05-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike. Cell Rep, 43, 2024
|
|
8ZC1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8zc1 by Molmil](/molmil-images/mine/8zc1) | SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, focused refinement of RBD region | Descriptor: | Heavy chain of D1F6 Fab, Light chain of D1F6 Fab, Spike protein S1 | Authors: | Liu, B, Gao, X, Li, Z, Chen, Q, He, J, Xiong, X. | Deposit date: | 2024-04-28 | Release date: | 2024-05-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.17 Å) | Cite: | An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike. Cell Rep, 43, 2024
|
|
8ZC4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8zc4 by Molmil](/molmil-images/mine/8zc4) | SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of D1F6 Fab, ... | Authors: | Liu, B, Gao, X, Li, Z, Chen, Q, He, J, Xiong, X. | Deposit date: | 2024-04-28 | Release date: | 2024-05-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike. Cell Rep, 43, 2024
|
|
8ZC0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8zc0 by Molmil](/molmil-images/mine/8zc0) | SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of D1F6 Fab, ... | Authors: | Liu, B, Gao, X, Li, Z, Chen, Q, He, J, Xiong, X. | Deposit date: | 2024-04-28 | Release date: | 2024-05-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.17 Å) | Cite: | An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike. Cell Rep, 43, 2024
|
|
4WAF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4waf by Molmil](/molmil-images/mine/4waf) | Crystal Structure of a novel tetrahydropyrazolo[1,5-a]pyrazine in an engineered PI3K alpha | Descriptor: | N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Knapp, M.S, Elling, R.A. | Deposit date: | 2014-08-29 | Release date: | 2014-12-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors. Acs Med.Chem.Lett., 6, 2015
|
|
6BOI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6boi by Molmil](/molmil-images/mine/6boi) | Crystal Structure of LdtMt2 (56-408) with a panipenem adduct at the active site cysteine-354 | Descriptor: | (3S,5R)-5-[(2R,3R)-1,3-dihydroxybutan-2-yl]-3-({(3R)-1-[(1E)-ethanimidoyl]pyrrolidin-3-yl}sulfanyl)-L-proline, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Saavedra, H, Bianchet, M.A. | Deposit date: | 2017-11-20 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Structures and Mechanism of Inhibition of Mycobacterium tuberculosis L,D-transpeptidase 2 by Panipenem To Be Published
|
|
3PJZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3pjz by Molmil](/molmil-images/mine/3pjz) | Crystal Structure of the Potassium Transporter TrkH from Vibrio parahaemolyticus | Descriptor: | POTASSIUM ION, Potassium uptake protein TrkH | Authors: | Cao, Y, Jin, X, Huang, H, Levin, E.J, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2010-11-10 | Release date: | 2011-01-19 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (3.506 Å) | Cite: | Crystal structure of a potassium ion transporter, TrkH. Nature, 471, 2011
|
|
3QNQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3qnq by Molmil](/molmil-images/mine/3qnq) | Crystal structure of the transporter ChbC, the IIC component from the N,N'-diacetylchitobiose-specific phosphotransferase system | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, PTS system, ... | Authors: | Cao, Y, Jin, X, Huang, H, Levin, E.J, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2011-02-08 | Release date: | 2011-04-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.295 Å) | Cite: | Crystal structure of a phosphorylation-coupled saccharide transporter. Nature, 473, 2011
|
|
8BJ7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bj7 by Molmil](/molmil-images/mine/8bj7) | |
4ZFQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4zfq by Molmil](/molmil-images/mine/4zfq) | Structure of M. tuberculosis (3,3) L,D-Transpeptidase, LdtMt5. (Meropenen-adduct form) | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, DI(HYDROXYETHYL)ETHER, L,D-transpeptidase 5 | Authors: | Basta, L, Ghosh, A, Lamichhane, G, Bianchet, M.A. | Deposit date: | 2015-04-21 | Release date: | 2015-09-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis. J.Biol.Chem., 290, 2015
|
|
6V4L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6v4l by Molmil](/molmil-images/mine/6v4l) | Structure of TrkH-TrkA in complex with ATPgammaS | Descriptor: | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Potassium uptake protein TrkA, Trk system potassium uptake protein TrkH | Authors: | Zhou, M, Zhang, H. | Deposit date: | 2019-11-27 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun, 11, 2020
|
|
6V4J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6v4j by Molmil](/molmil-images/mine/6v4j) | Structure of TrkH-TrkA in complex with ATP | Descriptor: | Potassium uptake protein TrkA, Trk system potassium uptake protein TrkH | Authors: | Zhou, M, Zhang, H. | Deposit date: | 2019-11-27 | Release date: | 2020-02-12 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun, 11, 2020
|
|
6V4K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6v4k by Molmil](/molmil-images/mine/6v4k) | Structure of TrkH-TrkA in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Potassium transporter peripheral membrane component, Trk system potassium uptake protein | Authors: | Zhou, M, Zhang, H. | Deposit date: | 2019-11-27 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.53004146 Å) | Cite: | TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun, 11, 2020
|
|
3HFJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hfj by Molmil](/molmil-images/mine/3hfj) | Bacillus anthracis nicotinate mononucleotide adenylytransferase (nadD) in complex with inhibitor CID 3289443 | Descriptor: | 3-amino-N-(3-fluorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide, CALCIUM ION, Nicotinate (Nicotinamide) nucleotide adenylyltransferase | Authors: | Zhang, H, Huang, N, Eyobo, Y. | Deposit date: | 2009-05-11 | Release date: | 2009-09-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Chem.Biol., 16, 2009
|
|
4J9V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j9v by Molmil](/molmil-images/mine/4j9v) | Crystal Structure of the TrkA Gating ring bound to ATP-gamma-S | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Potassium uptake protein TrkA, ... | Authors: | Huang, H, Levin, E.J, Jin, X, Cao, Y, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2013-02-17 | Release date: | 2013-04-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.051 Å) | Cite: | Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature, 496, 2013
|
|
4J9U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j9u by Molmil](/molmil-images/mine/4j9u) | Crystal Structure of the TrkH/TrkA potassium transport complex | Descriptor: | HEXATANTALUM DODECABROMIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, POTASSIUM ION, ... | Authors: | Cao, Y, Jin, X, Huang, H, Levin, E.J, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2013-02-17 | Release date: | 2013-04-03 | Last modified: | 2013-05-01 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature, 496, 2013
|
|
7XST
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xst by Molmil](/molmil-images/mine/7xst) | |
6L0X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6l0x by Molmil](/molmil-images/mine/6l0x) | The First Tudor Domain of PHF20L1 | Descriptor: | CITRIC ACID, GLYCEROL, PHD finger protein 20-like protein 1 | Authors: | Lv, M.Q, Gao, J. | Deposit date: | 2019-09-27 | Release date: | 2020-09-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
|
|
6L1P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6l1p by Molmil](/molmil-images/mine/6l1p) | Crystal structure of PHF20L1 in complex with Hit 1 | Descriptor: | 4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)phenol, GLYCEROL, PHD finger protein 20-like protein 1, ... | Authors: | Lv, M.Q, Gao, J. | Deposit date: | 2019-09-29 | Release date: | 2020-09-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.231 Å) | Cite: | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
|
|
6L1C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6l1c by Molmil](/molmil-images/mine/6l1c) | Crystal Structure Of of PHF20L1 Tudor1 Y24L mutant | Descriptor: | GLYCEROL, PHD finger protein 20-like protein 1, SULFATE ION | Authors: | Lv, M.Q, Gao, J. | Deposit date: | 2019-09-28 | Release date: | 2020-09-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
|
|
6L1I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6l1i by Molmil](/molmil-images/mine/6l1i) | Crystal Structure Of of PHF20L1 Tudor1 Y24W/Y29W mutant | Descriptor: | PHD finger protein 20-like protein 1, SULFATE ION | Authors: | Lv, M.Q, Gao, J. | Deposit date: | 2019-09-29 | Release date: | 2020-09-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
|
|
3NTC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ntc by Molmil](/molmil-images/mine/3ntc) | Crystal structure of KD-247 Fab, an anti-V3 antibody that inhibits HIV-1 Entry | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Fab heavy chain, ... | Authors: | Sarafianos, S.G, Kirby, K.A. | Deposit date: | 2010-07-03 | Release date: | 2010-08-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247. Faseb J., 29, 2015
|
|
5Y5W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5y5w by Molmil](/molmil-images/mine/5y5w) | |
7RX2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rx2 by Molmil](/molmil-images/mine/7rx2) | |