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3HFJ

Bacillus anthracis nicotinate mononucleotide adenylytransferase (nadD) in complex with inhibitor CID 3289443

Summary for 3HFJ
Entry DOI10.2210/pdb3hfj/pdb
DescriptorNicotinate (Nicotinamide) nucleotide adenylyltransferase, 3-amino-N-(3-fluorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide, CALCIUM ION, ... (4 entities in total)
Functional Keywordsenzyme-inhibitor complex, nad, nucleotidyltransferase, pyridine nucleotide biosynthesis, transferase
Biological sourceBacillus anthracis (anthrax,anthrax bacterium)
Total number of polymer chains2
Total formula weight44710.57
Authors
Zhang, H.,Huang, N.,Eyobo, Y. (deposition date: 2009-05-11, release date: 2009-09-08, Last modification date: 2024-02-21)
Primary citationSorci, L.,Pan, Y.,Eyobo, Y.,Rodionova, I.,Huang, N.,Kurnasov, O.,Zhong, S.,MacKerell, A.D.,Zhang, H.,Osterman, A.L.
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.
Chem.Biol., 16:849-861, 2009
Cited by
PubMed: 19716475
DOI: 10.1016/j.chembiol.2009.07.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.02 Å)
Structure validation

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