3HFJ
Bacillus anthracis nicotinate mononucleotide adenylytransferase (nadD) in complex with inhibitor CID 3289443
Summary for 3HFJ
Entry DOI | 10.2210/pdb3hfj/pdb |
Descriptor | Nicotinate (Nicotinamide) nucleotide adenylyltransferase, 3-amino-N-(3-fluorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | enzyme-inhibitor complex, nad, nucleotidyltransferase, pyridine nucleotide biosynthesis, transferase |
Biological source | Bacillus anthracis (anthrax,anthrax bacterium) |
Total number of polymer chains | 2 |
Total formula weight | 44710.57 |
Authors | |
Primary citation | Sorci, L.,Pan, Y.,Eyobo, Y.,Rodionova, I.,Huang, N.,Kurnasov, O.,Zhong, S.,MacKerell, A.D.,Zhang, H.,Osterman, A.L. Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Chem.Biol., 16:849-861, 2009 Cited by PubMed: 19716475DOI: 10.1016/j.chembiol.2009.07.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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