6V4L

Structure of TrkH-TrkA in complex with ATPgammaS

Summary for 6V4L

• Entry DOI: 10.2210/pdb6v4l/pdb
• Descriptor: Trk system potassium uptake protein TrkH, Potassium uptake protein TrkA, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER (3 entities in total)
• Functional Keywords: ion channel, transport protein
• Biological source: Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633); More
• Total number of polymer chains: 4
• Total formula weight: 208687.91

Authors

Zhou, M.,Zhang, H. (deposition date: 2019-11-27, release date: 2020-02-12, Last modification date: 2023-10-11)

• Primary citation: Zhang, H.,Pan, Y.,Hu, L.,Hudson, M.A.,Hofstetter, K.S.,Xu, Z.,Rong, M.,Wang, Z.,Prasad, B.V.V.,Lockless, S.W.,Chiu, W.,Zhou, M.; TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential.; Nat Commun, 11:547-547, 2020; PubMed: 31992706; DOI: 10.1038/s41467-019-14240-9

Experimental method

X-RAY DIFFRACTION (3.8 Å)