3NTC

Crystal structure of KD-247 Fab, an anti-V3 antibody that inhibits HIV-1 Entry

Summary for 3NTC

• Entry DOI: 10.2210/pdb3ntc/pdb
• Descriptor: Fab light chain, Fab heavy chain, SULFATE ION, ... (6 entities in total)
• Functional Keywords: kd-247, humanized antibody, anti-v3, fab, immune system
• Biological source: Homo sapiens, Mus musculus; More
• Total number of polymer chains: 2
• Total formula weight: 48558.80

Authors

Sarafianos, S.G.,Kirby, K.A. (deposition date: 2010-07-03, release date: 2010-08-25, Last modification date: 2023-09-06)

• Primary citation: Kirby, K.A.,Ong, Y.T.,Hachiya, A.,Laughlin, T.G.,Chiang, L.A.,Pan, Y.,Moran, J.L.,Marchand, B.,Singh, K.,Gallazzi, F.,Quinn, T.P.,Yoshimura, K.,Murakami, T.,Matsushita, S.,Sarafianos, S.G.; Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.; Faseb J., 29:70-80, 2015; PubMed: 25351987; DOI: 10.1096/fj.14-252262

Experimental method

X-RAY DIFFRACTION (1.55 Å)