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3L1Y
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BU of 3l1y by Molmil
Crystal structure of human UBC4 E2 conjugating enzyme
Descriptor: Ubiquitin-conjugating enzyme E2 D2
Authors:Benirschke, R, Thompson, J.R, Mer, G.
Deposit date:2009-12-14
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
3L1Z
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BU of 3l1z by Molmil
Crystal structure of the U-BOX domain of human E4B ubiquitin ligase in complex with UBCH5C E2 ubiquitin conjugating enzyme
Descriptor: Ubiquitin conjugation factor E4 B, Ubiquitin-conjugating enzyme E2 D3
Authors:Benirschke, R, Thompson, J.R, Mer, G.
Deposit date:2009-12-14
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
3L1X
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BU of 3l1x by Molmil
Crystal Structure of U-box Domain of Human E4B Ubiquitin Ligase
Descriptor: Ubiquitin conjugation factor E4 B
Authors:Benirschke, R, Thompson, J.R, Mer, G.
Deposit date:2009-12-14
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
6VE5
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BU of 6ve5 by Molmil
X-ray structure of human REV7 in complex with Shieldin3 (residues 41-74)
Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2019-12-28
Release date:2021-01-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
4V5B
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BU of 4v5b by Molmil
Structure of PDF binding helix in complex with the ribosome.
Descriptor: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
Authors:Bingel-Erlenmeyer, R, Kohler, R, Kramer, G, Sandikci, A, Antolic, S, Maier, T, Schaffitzel, C, Wiedmann, B, Bukau, B, Ban, N.
Deposit date:2007-11-22
Release date:2014-07-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.74 Å)
Cite:A Peptide Deformylase-Ribosome Complex Reveals Mechanism of Nascent Chain Processing.
Nature, 452, 2008
3SD4
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BU of 3sd4 by Molmil
Crystal structure of the first Tudor domain of human PHF20
Descriptor: PHD finger protein 20
Authors:Cui, G, Botuyan, M.V, Thompson, J.R, Mer, G.
Deposit date:2011-06-08
Release date:2011-06-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.928 Å)
Cite:PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012
7LYA
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BU of 7lya by Molmil
Cryo-EM structure of the human nucleosome core particle with linked histone proteins H2A and H2B
Descriptor: DNA (146-MER), DNA (147-MER), Histone H2A type 1-B/E, ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
Deposit date:2021-03-06
Release date:2021-07-28
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
7LYB
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BU of 7lyb by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c
Descriptor: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
Deposit date:2021-03-06
Release date:2021-07-28
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
3TVV
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BU of 3tvv by Molmil
Structure of the tandem PH domains of Rtt106 (residues 68-315)
Descriptor: Histone chaperone RTT106
Authors:Su, D, Thompson, J.R, Mer, G.
Deposit date:2011-09-20
Release date:2012-02-01
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.589 Å)
Cite:Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
Nature, 483, 2012
7LYC
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BU of 7lyc by Molmil
Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777)
Descriptor: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
Deposit date:2021-03-06
Release date:2021-06-16
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
3TW1
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BU of 3tw1 by Molmil
Structure of Rtt106-AHN
Descriptor: GLYCEROL, Histone chaperone RTT106, N-[2-(1H-IMIDAZOL-4-YL)ETHYL]ACETAMIDE
Authors:Su, D, Thompson, J.R, Mer, G.
Deposit date:2011-09-21
Release date:2012-02-01
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.772 Å)
Cite:Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
Nature, 483, 2012
3SZM
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BU of 3szm by Molmil
STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE
Descriptor: Histone H2A.x, Microcephalin
Authors:Singh, N, Thompson, J.R, Mer, G.
Deposit date:2011-07-19
Release date:2011-11-30
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proc.Natl.Acad.Sci.USA, 109, 2012
3FSS
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BU of 3fss by Molmil
Structure of the tandem PH domains of Rtt106
Descriptor: GLYCEROL, Histone chaperone RTT106, MALONIC ACID
Authors:Su, D, Thompson, J.R, Mer, G.
Deposit date:2009-01-11
Release date:2009-12-22
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.432 Å)
Cite:Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
Nature, 483, 2012
3T1N
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BU of 3t1n by Molmil
Structure of human MICROCEPHALIN (MCPH1) TANDEM BRCT domains in complex with a CDC27 phosphopeptide
Descriptor: Cdc27 peptide, Microcephalin
Authors:Singh, N, Thompson, J.R, Mer, G.
Deposit date:2011-07-22
Release date:2011-11-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex.
J.Biol.Chem., 287, 2012
6MXY
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BU of 6mxy by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351
Descriptor: N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION, TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.624 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXZ
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BU of 6mxz by Molmil
Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
Descriptor: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Schuller, D.J, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
3U3Z
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BU of 3u3z by Molmil
Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142
Descriptor: GLYCEROL, Histone H2A.X peptide, Microcephalin
Authors:Singh, N, Thompson, J.R, Heroux, A, Mer, G.
Deposit date:2011-10-06
Release date:2012-07-25
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proc.Natl.Acad.Sci.USA, 109, 2012
2B02
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BU of 2b02 by Molmil
Crystal Structure of ARNT PAS-B Domain
Descriptor: Aryl hydrocarbon receptor nuclear translocator
Authors:Lee, J, Botuyan, M.V, Nomine, Y, Ohh, M, Thompson, J.R, Mer, G.
Deposit date:2005-09-12
Release date:2006-10-24
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure and Binding Properties of ARNT PAS-B Heterodimerization Domain
To be Published
2K2W
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BU of 2k2w by Molmil
Second BRCT domain of NBS1
Descriptor: Recombination and DNA repair protein
Authors:Xu, C, Cui, G, Botuyan, M, Mer, G.
Deposit date:2008-04-14
Release date:2008-06-17
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.
J.Mol.Biol., 381, 2008
7KLZ
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BU of 7klz by Molmil
Structure of SPOP MATH domain in complex with a Geminin peptide
Descriptor: Geminin peptide, PHOSPHATE ION, Speckle-type POZ protein
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2020-11-01
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Nat Commun, 12, 2021
2QQR
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BU of 2qqr by Molmil
JMJD2A hybrid tudor domains
Descriptor: JmjC domain-containing histone demethylation protein 3A, SULFATE ION
Authors:Lee, J, Botuyan, M.V, Mer, G.
Deposit date:2007-07-26
Release date:2007-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Nat.Struct.Mol.Biol., 15, 2008
2QQS
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BU of 2qqs by Molmil
JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide
Descriptor: JmjC domain-containing histone demethylation protein 3A, METHYLATED HISTONE H4 PEPTIDE
Authors:Lee, J, Botuyan, M.V, Mer, G.
Deposit date:2007-07-26
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Nat.Struct.Mol.Biol., 15, 2008
7LXD
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BU of 7lxd by Molmil
Structure of yeast DNA Polymerase Zeta (apo)
Descriptor: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
Authors:Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R.
Deposit date:2021-03-03
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
7LIN
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BU of 7lin by Molmil
X-ray structure of SPOP MATH domain (D140G) in complex with a 53BP1 peptide
Descriptor: SULFATE ION, Speckle-type POZ protein, TP53-binding protein 1 peptide
Authors:Botuyan, M.V, Cui, G, Mer, G.
Deposit date:2021-01-27
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021
7LIO
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BU of 7lio by Molmil
X-ray structure of SPOP MATH domain (S119D) in complex with a 53BP1 peptide
Descriptor: Speckle-type POZ protein, TP53-binding protein 1 peptide
Authors:Botuyan, M.V, Cui, G, Mer, G.
Deposit date:2021-01-27
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021

223532

数据于2024-08-07公开中

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