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8EK9
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BU of 8ek9 by Molmil
Crystal structure of the class A carbapenemase CRH-1 in complex with avibactam at 1.4 Angstrom resolution
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase
Authors:Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S.
Deposit date:2022-09-20
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases.
Antimicrob.Agents Chemother., 67, 2023
8EHU
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BU of 8ehu by Molmil
Crystal structure of the environmental CRH-1 class A carbapenemase at 1.1 Angstrom resolution
Descriptor: Beta-lactamase
Authors:Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S.
Deposit date:2022-09-14
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases.
Antimicrob.Agents Chemother., 67, 2023
8EO7
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BU of 8eo7 by Molmil
Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution
Descriptor: beta-lactamase
Authors:Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S.
Deposit date:2022-10-02
Release date:2023-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions
to be published
8EO6
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BU of 8eo6 by Molmil
Crystal structure of metagenomic class A beta-lactamase precursor LRA-5 in complex with ceftazidime at 2.35 Angstrom resolution
Descriptor: ACYLATED CEFTAZIDIME, LRA-5
Authors:Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S.
Deposit date:2022-10-02
Release date:2023-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions
to be published
8EHH
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BU of 8ehh by Molmil
Crystal structure of the class A extended-spectrum beta-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution
Descriptor: (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase
Authors:Power, P, Ghiglione, B, Bonomo, R.A, Rodriguez, M.M, Gutkind, G, Klinke, S.
Deposit date:2022-09-14
Release date:2023-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Biochemical and structural evidences of the activity of relebactam as inhibitor of the extended-spectrum beta-lactamase CTX-M-96.
To be published
4GQN
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BU of 4gqn by Molmil
Crystallographic structure of trimeric Riboflavin Synthase from Brucella abortus in complex with 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione
Descriptor: 5-NITRO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, Riboflavin synthase subunit alpha
Authors:Serer, M.I, Bonomi, H.R, Guimaraes, B.G, Rossi, R.C, Goldbaum, F.A, Klinke, S.
Deposit date:2012-08-23
Release date:2014-03-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility.
Acta Crystallogr.,Sect.D, 70, 2014
8EO5
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BU of 8eo5 by Molmil
Crystal structure of the class A beta-lactamase precursor LRA-5 from an Alaskan soil metagenome at 1.8 Angstrom resolution
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LRA-5
Authors:Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S.
Deposit date:2022-10-02
Release date:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions
to be published
6UCT
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BU of 6uct by Molmil
Crystal structure of Mal de Rio Cuarto virus P9-1 viroplasm protein (C-arm deletion mutant)
Descriptor: p9-1
Authors:Llauger, G, Klinke, S, Monti, D, Sycz, G, Cerutti, M.L, Goldbaum, F.A, del Vas, M, Otero, L.H.
Deposit date:2019-09-17
Release date:2021-03-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Crystal structure of Mal de Rio Cuarto virus P9-1 viroplasm protein (C-arm deletion mutant)
To Be Published
6VAW
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BU of 6vaw by Molmil
Peanut lectin complexed with N-beta-D-galactopyranosyl-L-succinamoyl derivative (NGS)
Descriptor: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
Authors:Otero, L.H, Primo, E.D, Cagnoni, A.J, Klinke, S, Goldbaum, F.A, Uhrig, M.L.
Deposit date:2019-12-18
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands.
Acta Crystallogr D Struct Biol, 76, 2020
6VC4
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BU of 6vc4 by Molmil
Peanut lectin complexed with S-beta-D-Thiogalactopyranosyl beta-D-glucopyranoside derivative (STGD)
Descriptor: (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5S,6S)-3,4,5-trihydroxy-6-({[(1-{[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl]methyl}-1H-1,2,3-triazol-4-yl)methyl]sulfanyl}methyl)tetrahydro-2H-pyran-2-yl]sulfanyl}tetrahydro-2H-pyran-3,4,5-triol (non-preferred name), CALCIUM ION, Galactose-binding lectin, ...
Authors:Otero, L.H, Primo, E.D, Cagnoni, A.J, Cano, M.E, Klinke, S, Goldbaum, F.A, Uhrig, M.L.
Deposit date:2019-12-20
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands.
Acta Crystallogr D Struct Biol, 76, 2020
6VAV
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BU of 6vav by Molmil
Peanut lectin complexed with divalent N-beta-D-galactopyranosyl-L-succinamoyl derivative (diNGS)
Descriptor: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
Authors:Otero, L.H, Primo, E.D, Cagnoni, A.J, Klinke, S, Goldbaum, F.A, Uhrig, M.L.
Deposit date:2019-12-18
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands.
Acta Crystallogr D Struct Biol, 76, 2020
6VC3
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BU of 6vc3 by Molmil
Peanut lectin complexed with S-beta-D-thiogalactopyranosyl 6-deoxy-6-S-propynyl-beta-D-glucopyranoside (STG)
Descriptor: 6-S-(prop-2-yn-1-yl)-6-thio-beta-D-glucopyranosyl 1-thio-beta-D-galactopyranoside, CALCIUM ION, Galactose-binding lectin, ...
Authors:Otero, L.H, Primo, E.D, Cagnoni, A.J, Cano, M.E, Klinke, S, Goldbaum, F.A, Uhrig, M.L.
Deposit date:2019-12-20
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands.
Acta Crystallogr D Struct Biol, 76, 2020
6V95
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BU of 6v95 by Molmil
Peanut lectin complexed with divalent N-beta-D-galactopyranosyl-L-tartaramidoyl derivative (diNGT)
Descriptor: (2R,3R)-N-[(1-{(3S,3aR,6S,6aR)-6-[4-({[(2R,3R)-2,3-dihydroxy-4-oxo-4-{[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino}butanoyl]amino}methyl)-1H-1,2,3-triazol-1-yl]hexahydrofuro[3,2-b]furan-3-yl}-1H-1,2,3-triazol-4-yl)methyl]-2,3-dihydroxy-N'-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]butanediamide (non-preferred name), CALCIUM ION, Galactose-binding lectin, ...
Authors:Otero, L.H, Primo, E.D, Cagnoni, A.J, Klinke, S, Goldbaum, F.A, Uhrig, M.L.
Deposit date:2019-12-13
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands.
Acta Crystallogr D Struct Biol, 76, 2020
6VGF
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BU of 6vgf by Molmil
Peanut lectin complexed with divalent S-beta-D-thiogalactopyranosyl beta-D-glucopyranoside derivative (diSTGD)
Descriptor: (2S,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5S,6S)-3,4,5-trihydroxy-6-({[(1-{[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({4-[({[(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]sulfanyl}tetrahydro-2H-pyran-2-yl]methyl}sulfanyl)methyl]-1H-1,2,3-triazol-1-yl}methyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]methyl}-1H-1,2,3-triazol-4-yl)methyl]sulfanyl}methyl)tetrahydro-2H-pyran-2-yl]sulfanyl}tetrahydro-2H-pyran-3,4,5-triol, CALCIUM ION, Galactose-binding lectin, ...
Authors:Otero, L.H, Primo, E.D, Cagnoni, A.J, Cano, M.E, Klinke, S, Goldbaum, F.A, Uhrig, M.L.
Deposit date:2020-01-08
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands.
Acta Crystallogr D Struct Biol, 76, 2020
6CAC
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BU of 6cac by Molmil
Crystal structure of NDM-1 metallo-beta-lactamase harboring an insertion of a Pro residue in L3 loop
Descriptor: CADMIUM ION, CALCIUM ION, COBALT (II) ION, ...
Authors:Alzari, P.M, Giannini, E, Palacios, A, Mojica, M, Bonomo, R, Llarrull, L, Vila, A.
Deposit date:2018-01-30
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob. Agents Chemother., 63, 2019
3N4W
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BU of 3n4w by Molmil
Crystal structure of an abridged SER to ALA mutant of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at pH 7.5
Descriptor: CALCIUM ION, Receptor-type tyrosine-protein phosphatase-like N
Authors:Primo, M.E, Jakoncic, J, Poskus, E, Ermacora, M.R.
Deposit date:2010-05-23
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.
J.Biol.Chem., 283, 2008
3NG8
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BU of 3ng8 by Molmil
Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5
Descriptor: CALCIUM ION, Receptor-type tyrosine-protein phosphatase-like N
Authors:Primo, M.E, Jakoncic, J, Poskus, E, Ermacora, M.R.
Deposit date:2010-06-11
Release date:2010-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.
J.Biol.Chem., 283, 2008
7R63
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BU of 7r63 by Molmil
Nb82, a nanobody against voltage gated sodium channels Nav1.4 and Nav1.5
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, Nanobody Nb82, ...
Authors:Srinivasan, L, Gabelli, S.B.
Deposit date:2021-06-22
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of high-affinity nanobodies specific for Na V 1.4 and Na V 1.5 voltage-gated sodium channel isoforms.
J.Biol.Chem., 298, 2022
2MPB
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BU of 2mpb by Molmil
NMR structure of BA42 protein from the psychrophilic bacteria Bizionia argentinensis sp. nov
Descriptor: BA42
Authors:Cicero, D, Aran, M, Smal, C, Pellizza, L, Gallo, M.
Deposit date:2014-05-14
Release date:2014-08-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution and crystal structure of BA42, a protein from the Antarctic bacterium Bizionia argentinensis comprised of a stand-alone TPM domain.
Proteins, 82, 2014
4D4Z
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BU of 4d4z by Molmil
STRUCTURE OF HUMAN DEOXYHYPUSINE HYDROXYLASE in complex with glycerol
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DEOXYHYPUSINE HYDROXYLASE, FE (III) ION, ...
Authors:Han, Z, Sakai, N, Hilgenfeld, R.
Deposit date:2014-10-31
Release date:2015-04-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the Peroxo-Diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.
Structure, 23, 2015
4D50
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BU of 4d50 by Molmil
Structure of human deoxyhypusine hydroxylase
Descriptor: DEOXYHYPUSINE HYDROXYLASE, FE (III) ION, GUANIDINE, ...
Authors:Han, Z, Sakai, N, Hilgenfeld, R.
Deposit date:2014-10-31
Release date:2015-04-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the Peroxo-Diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.
Structure, 23, 2015
8STL
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BU of 8stl by Molmil
Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha
Descriptor: Nanobody PIK3_Nb16, SULFATE ION
Authors:Nwafor, J.N, Srinivasan, L, Chen, Z, Gabelli, S.B, Iheanacho, A, Alzogaray, V, Klinke, S.
Deposit date:2023-05-10
Release date:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Development of isoform specific nanobodies for Class I PI3Ks
To be published
3NP5
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BU of 3np5 by Molmil
Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5
Descriptor: CALCIUM ION, Receptor-type tyrosine-protein phosphatase-like N
Authors:Primo, M.E, Jakoncic, J, Poskus, E, Ermacora, M.R.
Deposit date:2010-06-27
Release date:2010-12-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Receptor-Type Protein-Tyrosine Phosphatase Ia-2-Ica512
To be Published
3N01
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BU of 3n01 by Molmil
Crystal structure of an abridged form of the mature ectodomain of the Human Receptor-Type Protein Tyrosine Phosphatase ICA512/IA-2 at pH 8.5
Descriptor: CALCIUM ION, Receptor-type tyrosine-protein phosphatase-like N
Authors:Primo, M.E, Jakoncic, J, Poskus, E, Ermacora, M.R.
Deposit date:2010-05-13
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Receptor-type Protein-Tyrosine Phosphatase IA-2-ICA512
To be Published
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221716

数据于2024-06-26公开中

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