7R63

Nb82, a nanobody against voltage gated sodium channels Nav1.4 and Nav1.5

Summary for 7R63

• Entry DOI: 10.2210/pdb7r63/pdb
• Descriptor: Nanobody Nb82, SULFATE ION, 2-(2-METHOXYETHOXY)ETHANOL, ... (6 entities in total)
• Functional Keywords: nanobody, vhh, nav1.4, nav1.5, voltage-gated sodium channel, scn4a, scn5a, immune system
• Biological source: Lama glama (Llama)
• Total number of polymer chains: 4
• Total formula weight: 62139.68

Authors

Srinivasan, L.,Gabelli, S.B. (deposition date: 2021-06-22, release date: 2022-05-04, Last modification date: 2023-10-18)

• Primary citation: Srinivasan, L.,Alzogaray, V.,Selvakumar, D.,Nathan, S.,Yoder, J.B.,Wright, K.M.,Klinke, S.,Nwafor, J.N.,Labanda, M.S.,Goldbaum, F.A.,Schon, A.,Freire, E.,Tomaselli, G.F.,Amzel, L.M.,Ben-Johny, M.,Gabelli, S.B.; Development of high-affinity nanobodies specific for Na V 1.4 and Na V 1.5 voltage-gated sodium channel isoforms.; J.Biol.Chem., 298:101763-101763, 2022; PubMed: 35202650; DOI: 10.1016/j.jbc.2022.101763

Experimental method

X-RAY DIFFRACTION (2 Å)