6BPF

CTX-M-151 class A extended-spectrum beta-lactamase crystal structure in complex with avibactam at 1.32 Angstrom resolution

Summary for 6BPF

Entry DOI	10.2210/pdb6bpf/pdb
Descriptor	Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total)
Functional Keywords	beta-lactamase; dbo; diazabicyclooctane; penicilloil-serine-transferase; antibiotic resistance, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Salmonella enterica
Total number of polymer chains	1
Total formula weight	28626.33
Authors	Power, P.,Ghiglione, B.,Rodriguez, M.M.,Gutkind, G.,Ishii, Y.,Bonomo, R.A.,Klinke, S. (deposition date: 2017-11-23, release date: 2018-11-28, Last modification date: 2023-10-04)
Primary citation	Ghiglione, B.,Rodriguez, M.M.,Brunetti, F.,Papp-Wallace, K.M.,Yoshizumi, A.,Ishii, Y.,Bonomo, R.A.,Gutkind, G.,Klinke, S.,Power, P. Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam. Antimicrob.Agents Chemother., 65:-, 2021 Cited by PubMed: 33431411 DOI: 10.1128/AAC.01757-20 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.318 Å)

Structure validation