8DQT

Human PDK1 kinase domain in complex with Valsartan

Summary for 8DQT

Entry DOI	10.2210/pdb8dqt/pdb
Related	3HRC 3HRF 4AW1
Descriptor	3-phosphoinositide-dependent protein kinase 1, (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	agc kinase, phosphorylation, pdk1, pif-pocket, alpha-c helix, phosphoprotein, serine/threonine-protein kinase, kinase transferase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36791.22
Authors	Gross, L.Z.F.,Klinke, S.,Biondi, R.M. (deposition date: 2022-07-19, release date: 2023-06-21, Last modification date: 2023-10-25)
Primary citation	Sacerdoti, M.,Gross, L.Z.F.,Riley, A.M.,Zehnder, K.,Ghode, A.,Klinke, S.,Anand, G.S.,Paris, K.,Winkel, A.,Herbrand, A.K.,Godage, H.Y.,Cozier, G.E.,Suss, E.,Schulze, J.O.,Pastor-Flores, D.,Bollini, M.,Cappellari, M.V.,Svergun, D.,Grawert, M.A.,Aramendia, P.F.,Leroux, A.E.,Potter, B.V.L.,Camacho, C.J.,Biondi, R.M. Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein. Sci.Signal., 16:eadd3184-eadd3184, 2023 Cited by PubMed: 37311034 DOI: 10.1126/scisignal.add3184 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation