3HRF
Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket
Summary for 3HRF
Entry DOI | 10.2210/pdb3hrf/pdb |
Related | 3HRC |
Descriptor | 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid, ... (5 entities in total) |
Functional Keywords | agc kinase, phosphorylation, allostery, pdk1, pif-pocket, alpha-c helix, activation loop, atp binding, atp-binding, kinase, membrane, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 36663.11 |
Authors | Hindie, V.,Alzari, P.M.,Biondi, R.M. (deposition date: 2009-06-09, release date: 2009-09-15, Last modification date: 2023-11-01) |
Primary citation | Hindie, V.,Stroba, A.,Zhang, H.,Lopez-Garcia, L.A.,Idrissova, L.,Zeuzem, S.,Hirschberg, D.,Schaeffer, F.,Jrgensen, T.J.,Engel, M.,Alzari, P.M.,Biondi, R.M. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol., 5:758-764, 2009 Cited by PubMed: 19718043DOI: 10.1038/nchembio.208 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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