3NG8

Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5

Summary for 3NG8

Entry DOI	10.2210/pdb3ng8/pdb
Related	2QT7 3N0I 3N4W
Descriptor	Receptor-type tyrosine-protein phosphatase-like N, CALCIUM ION (3 entities in total)
Functional Keywords	ia-2, ica-512, protein-tyrosine phosphatase, transmembrane protein, diabetes, autoimmunity, proteolysis, glycoprotein, receptor, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: Q16849
Total number of polymer chains	2
Total formula weight	19283.91
Authors	Primo, M.E.,Jakoncic, J.,Poskus, E.,Ermacora, M.R. (deposition date: 2010-06-11, release date: 2010-12-15, Last modification date: 2023-09-06)
Primary citation	Primo, M.E.,Klinke, S.,Sica, M.P.,Goldbaum, F.A.,Jakoncic, J.,Poskus, E.,Ermacora, M.R. Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2. J.Biol.Chem., 283:4674-4681, 2008 Cited by PubMed: 18048354 DOI: 10.1074/jbc.M708144200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation