8EO5

Crystal structure of the class A beta-lactamase precursor LRA-5 from an Alaskan soil metagenome at 1.8 Angstrom resolution

Summary for 8EO5

• Entry DOI: 10.2210/pdb8eo5/pdb
• Descriptor: LRA-5, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total)
• Functional Keywords: beta-lactamase precursor, environmental resistome, soil metagenome, antimicrobial protein
• Biological source: uncultured soil bacterium
• Total number of polymer chains: 2
• Total formula weight: 62076.96

Authors

Power, P.,D'Amico Gonzalez, G.,Centron, D.,Gutkind, G.,Handelsman, J.,Klinke, S. (deposition date: 2022-10-02, release date: 2023-09-06)

• Primary citation: D'Amico Gonzalez, G.,Handelsman, J.,Centron, D.,Gutkind, G.,Klinke, S.,Power, P.; Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions; to be published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)