7X7A
 
 | | Cryo-EM structure of SbCas7-11 in complex with crRNA and target RNA | | Descriptor: | RAMP superfamily protein, RNA (33-MER), ZINC ION | | Authors: | Yu, G, Wang, X, Deng, Z, Zhang, H. | | Deposit date: | 2022-03-09 | | Release date: | 2022-11-16 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex.
Nat Microbiol, 7, 2022
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7EB6
 | | Crystal structure of GTP-binding protein-like domain of AGAP1 | | Descriptor: | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 | | Authors: | Cheng, N, Zhang, H, Zhang, S, Ma, X, Meng, G. | | Deposit date: | 2021-03-09 | | Release date: | 2021-04-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.014 Å) | | Cite: | Crystal structure of the GTP-binding protein-like domain of AGAP1.
Acta Crystallogr.,Sect.F, 77, 2021
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7EB2
 | | Cryo-EM structure of human GABA(B) receptor-Gi protein complex | | Descriptor: | (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ... | | Authors: | Shen, C, Mao, C, Xu, C, Jin, N, Zhang, H, Shen, D, Shen, Q, Wang, X, Hou, T, Rondard, P, Chen, Z, Pin, J, Zhang, Y, Liu, J. | | Deposit date: | 2021-03-08 | | Release date: | 2021-05-05 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of GABA B receptor-G i protein coupling.
Nature, 594, 2021
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7XOU
 | | Structural insights into human brain gut peptide cholecystokinin receptors | | Descriptor: | CCK-8, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | | Deposit date: | 2022-05-01 | | Release date: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
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7XOV
 | | Structural insights into human brain gut peptide cholecystokinin receptors | | Descriptor: | 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | | Deposit date: | 2022-05-01 | | Release date: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
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7XOW
 | | Structural insights into human brain gut peptide cholecystokinin receptors | | Descriptor: | Gastrin, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | | Deposit date: | 2022-05-01 | | Release date: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
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7XW9
 | | Cryo-EM structure of the TRH-bound human TRHR-Gq complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | Authors: | Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y. | | Deposit date: | 2022-05-26 | | Release date: | 2022-12-28 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular basis for the activation of thyrotropin-releasing hormone receptor.
Cell Discov, 8, 2022
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7WIG
 | | Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | | Deposit date: | 2022-01-03 | | Release date: | 2022-06-01 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
Cell Res., 32, 2022
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7WIC
 | | Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | | Deposit date: | 2022-01-03 | | Release date: | 2022-06-01 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
Cell Res., 32, 2022
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8X7A
 | | Treprostinil bound Prostacyclin Receptor G protein complex | | Descriptor: | 2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | | Deposit date: | 2023-11-23 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024
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8X79
 | | MRE-269 bound Prostacyclin Receptor G protein complex | | Descriptor: | 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | | Deposit date: | 2023-11-23 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024
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7W3Z
 | | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin Releasing Peptide and Gq heterotrimers | | Descriptor: | Gastrin Releasing Peptide PRGNHWAVGHLM(NH2), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhan, Y, Peng, S, Zhang, H. | | Deposit date: | 2021-11-26 | | Release date: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7W40
 | | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] and Gq heterotrimers | | Descriptor: | Bombesin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhan, Y, Peng, S, Zhang, H. | | Deposit date: | 2021-11-26 | | Release date: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7W41
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7D8H
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7D9V
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7D8P
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8I23
 | | Clostridium thermocellum RNA polymerase transcription open complex with SigI1 and its promoter | | Descriptor: | DNA (80-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Li, J, Zhang, H, Li, D, Feng, Y, Zhu, P. | | Deposit date: | 2023-01-13 | | Release date: | 2023-10-11 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Structure of the transcription open complex of distinct sigma I factors.
Nat Commun, 14, 2023
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8I24
 | | Clostridium thermocellum RNA polymerase transcription open complex with SigI6 and its promoter | | Descriptor: | DNA (80-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Li, J, Zhang, H, Li, D, Feng, Y, Zhu, P. | | Deposit date: | 2023-01-13 | | Release date: | 2023-10-11 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structure of the transcription open complex of distinct sigma I factors.
Nat Commun, 14, 2023
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7ETR
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7F61
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7JLX
 | | Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ (TIR domains) | | Descriptor: | Disease resistance protein Roq1 | | Authors: | Martin, R, Qi, T, Zhang, H, Lui, F, King, M, Toth, C, Nogales, E, Staskawicz, B.J. | | Deposit date: | 2020-07-30 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
Science, 370, 2020
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7JLU
 | | Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ | | Descriptor: | CALCIUM ION, Disease resistance protein Roq1, XopQ | | Authors: | Martin, R, Qi, T, Zhang, H, Lui, F, King, M, Toth, C, Nogales, E, Staskawicz, B.J. | | Deposit date: | 2020-07-30 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
Science, 370, 2020
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7JLV
 | | Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Disease resistance protein Roq1, MAGNESIUM ION | | Authors: | Martin, R, Qi, T, Zhang, H, Lui, F, King, M, Toth, C, Nogales, E, Staskawicz, B.J. | | Deposit date: | 2020-07-30 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
Science, 370, 2020
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7W7H
 | | S Suis FakA-FakB2 complex structure | | Descriptor: | OLEIC ACID, Predicted kinase related to dihydroxyacetone kinase, SULFATE ION, ... | | Authors: | Shi, Y, Zang, N, Lou, N, Xu, Y, Sun, J, Huang, M, Zhang, H, Lu, H, Zhou, C, Feng, Y. | | Deposit date: | 2021-12-04 | | Release date: | 2022-09-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging.
Sci Adv, 8, 2022
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