7F61

Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746

Summary for 7F61

• Entry DOI: 10.2210/pdb7f61/pdb
• Descriptor: Histamine H3 receptor, Soluble cytochrome b562, N-ethyl-3-fluoranyl-3-[3-fluoranyl-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide, ... (5 entities in total)
• Functional Keywords: gpcr, histamine receptor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62550.11

Authors

Peng, X.,Zhang, H. (deposition date: 2021-06-23, release date: 2022-10-26, Last modification date: 2023-11-29)

• Primary citation: Peng, X.,Yang, L.,Liu, Z.,Lou, S.,Mei, S.,Li, M.,Chen, Z.,Zhang, H.; Structural basis for recognition of antihistamine drug by human histamine receptor.; Nat Commun, 13:6105-6105, 2022; PubMed: 36243875; DOI: 10.1038/s41467-022-33880-y

Experimental method

X-RAY DIFFRACTION (2.6 Å)