7F61
Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histamine H3 receptor | polymer | 407 | 45009.2 | 1 | UniProt (Q9Y5N1) Pfam (PF00001) | Homo sapiens (Human) | H3R,HH3R,G-protein coupled receptor 97 |
| 2 | B (B) | Soluble cytochrome b562 | polymer | 147 | 16831.9 | 1 | UniProt (P0ABE7) | Escherichia coli | Cytochrome b-562 |
| 3 | C (A) | N-ethyl-3-fluoranyl-3-[3-fluoranyl-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide | non-polymer | 322.4 | 1 | Chemie (1IB) PubChem (16119086) | |||
| 4 | D (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 5 | E (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 27 - 433 (UniProt: Q9Y5N1)
B: 1 - 106 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Lys 121 | Ser 121 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -40 | - | initiating methionine |
| Lys -39 | - | expression tag |
| Thr -38 | - | expression tag |
| Ile -37 | - | expression tag |
| Ile -36 | - | expression tag |
| Ala -35 | - | expression tag |
| Leu -34 | - | expression tag |
| Ser -33 | - | expression tag |
| Tyr -32 | - | expression tag |
| Ile -31 | - | expression tag |
| Phe -30 | - | expression tag |
| Cys -29 | - | expression tag |
| Leu -28 | - | expression tag |
| Val -27 | - | expression tag |
| Phe -26 | - | expression tag |
| Ala -25 | - | expression tag |
| Asp -24 | - | expression tag |
| Tyr -23 | - | expression tag |
| Lys -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Lys -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Trp 7 | Met 29 | engineered mutation |
| Ile 102 | His 124 | engineered mutation |
| Leu 106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61841.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 709.0 | |
| All* | Total formula weight | 62550.1 |
