7F61
Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histamine H3 receptor | polymer | 407 | 45009.2 | 1 | UniProt (Q9Y5N1) Pfam (PF00001) In PDB | Homo sapiens (Human) | H3R,HH3R,G-protein coupled receptor 97 |
| 2 | B | Soluble cytochrome b562 | polymer | 147 | 16831.9 | 1 | UniProt (P0ABE7) Pfam (PF07361) In PDB | Escherichia coli | Cytochrome b-562 |
| 3 | A | N-ethyl-3-fluoranyl-3-[3-fluoranyl-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide | non-polymer | 322.4 | 1 | Chemie (1IB) | |||
| 4 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 5 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 27 - 433 (UniProt: Q9Y5N1)
B: 1 - 106 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Lys 121 | Ser 121 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -40 | - | initiating methionine |
| Lys -39 | - | expression tag |
| Thr -38 | - | expression tag |
| Ile -37 | - | expression tag |
| Ile -36 | - | expression tag |
| Ala -35 | - | expression tag |
| Leu -34 | - | expression tag |
| Ser -33 | - | expression tag |
| Tyr -32 | - | expression tag |
| Ile -31 | - | expression tag |
| Phe -30 | - | expression tag |
| Cys -29 | - | expression tag |
| Leu -28 | - | expression tag |
| Val -27 | - | expression tag |
| Phe -26 | - | expression tag |
| Ala -25 | - | expression tag |
| Asp -24 | - | expression tag |
| Tyr -23 | - | expression tag |
| Lys -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Lys -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Trp 7 | Met 29 | engineered mutation |
| Ile 102 | His 124 | engineered mutation |
| Leu 106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61841.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 709.0 | |
| All* | Total formula weight | 62550.1 |
