8DED
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![BU of 8ded by Molmil](/molmil-images/mine/8ded) | Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW19 fab | Descriptor: | SKW19 Fab heavy chain, SKW19 Fab light chain, Spike glycoprotein E1, ... | Authors: | Pletnev, S, Tsybovsky, Y, Verardi, R, Roedeger, M, Kwong, P. | Deposit date: | 2022-06-20 | Release date: | 2023-07-05 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8DEE
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![BU of 8dee by Molmil](/molmil-images/mine/8dee) | Asymmetric Unit of Western Equine Encephalitis Virus | Descriptor: | Capsid protein, Spike glycoprotein E1, Spike glycoprotein E2 | Authors: | Pletnev, S, Verardi, R, Roedeger, M, Kwong, P. | Deposit date: | 2022-06-20 | Release date: | 2023-07-05 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8DEF
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![BU of 8def by Molmil](/molmil-images/mine/8def) | Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW24 fab | Descriptor: | SKW24 Fab heavy chain, SKW24 Fab light chain, Spike glycoprotein E1, ... | Authors: | Pletnev, S, Tsybovsky, Y, Verardi, R, Roedeger, M, Kwong, P.D. | Deposit date: | 2022-06-20 | Release date: | 2023-07-05 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8DUA
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![BU of 8dua by Molmil](/molmil-images/mine/8dua) | SIV E660.CR54 SOS-2P Env Trimer with ITS92.02 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, Envelope glycoprotein gp41, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2022-07-27 | Release date: | 2022-10-26 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (4.32 Å) | Cite: | Cryo-EM structures of prefusion SIV envelope trimer. Nat.Struct.Mol.Biol., 29, 2022
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8DVD
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![BU of 8dvd by Molmil](/molmil-images/mine/8dvd) | |
7ELG
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![BU of 7elg by Molmil](/molmil-images/mine/7elg) | LC3B modificated with a covalent probe | Descriptor: | 2-methylidene-5-thiophen-2-yl-cyclohexane-1,3-dione, Microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION | Authors: | Fan, S, Wan, W. | Deposit date: | 2021-04-10 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
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6KYF
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![BU of 6kyf by Molmil](/molmil-images/mine/6kyf) | Crystal structure of an anti-CRISPR protein | Descriptor: | AcrF11, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Niu, Y, Wang, H, Zhang, Y, Feng, Y. | Deposit date: | 2019-09-18 | Release date: | 2020-09-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation. Mol.Cell, 80, 2020
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4YDL
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![BU of 4ydl by Molmil](/molmil-images/mine/4ydl) | Crystal structure of broadly and potently neutralizing antibody C38-VRC18.02 in complex with HIV-1 clade AE strain 93TH057gp120 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Envelope glycoprotein gp160,Envelope glycoprotein gp160, ... | Authors: | Zhou, T, Srivatsan, S, Kwong, P.D. | Deposit date: | 2015-02-22 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
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6LAD
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![BU of 6lad by Molmil](/molmil-images/mine/6lad) | |
4YE4
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![BU of 4ye4 by Molmil](/molmil-images/mine/4ye4) | Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HT593.1 gp120, Heavy chain human antibody HJ16, ... | Authors: | Kwong, P.D, Chen, L, Zhou, T. | Deposit date: | 2015-02-23 | Release date: | 2015-07-22 | Last modified: | 2022-03-30 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
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4YFL
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![BU of 4yfl by Molmil](/molmil-images/mine/4yfl) | Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120 | Descriptor: | 1B2530 Light chain, 1B2530 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Acharya, P, Zhou, T, Moquin, S, Kwong, P.D. | Deposit date: | 2015-02-25 | Release date: | 2015-06-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.387 Å) | Cite: | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
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8DUL
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![BU of 8dul by Molmil](/molmil-images/mine/8dul) | Cryo-EM Structure of Antibody SKT05 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab SKT05 heavy chain, ... | Authors: | Cerutti, G, Verardi, R, Roederer, M, Shapiro, L. | Deposit date: | 2022-07-27 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (4.17 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8DUN
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![BU of 8dun by Molmil](/molmil-images/mine/8dun) | Cryo-EM Structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody SKW11 heavy chain, ... | Authors: | Cerutti, G, Verardi, R, Roederer, M, Shapiro, L. | Deposit date: | 2022-07-27 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (5.84 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8EEU
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![BU of 8eeu by Molmil](/molmil-images/mine/8eeu) | Venezuelan equine encephalitis virus-like particle in complex with Fab SKT05 | Descriptor: | Coat protein, Fab SKT05 heavy chain, Fab SKT05 light chain | Authors: | Tsybovsky, Y, Pletnev, S, Verardi, R, Roederer, M, Kwong, P.D. | Deposit date: | 2022-09-07 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8DWO
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![BU of 8dwo by Molmil](/molmil-images/mine/8dwo) | Cryo-EM Structure of Eastern Equine Encephalitis Virus in complex with SKE26 Fab | Descriptor: | Envelope glycoprotein E1, Envelope glycoprotein E2, SKE26 Fab Heavy Chain, ... | Authors: | Pletnev, S, Verardi, R, Roedeger, M, Kwong, P. | Deposit date: | 2022-08-01 | Release date: | 2023-07-19 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8EEV
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![BU of 8eev by Molmil](/molmil-images/mine/8eev) | Venezuelan equine encephalitis virus-like particle in complex with Fab SKT-20 | Descriptor: | Coat protein, Fab SKT20 heavy chain, Fab SKT20 light chain | Authors: | Tsybovsky, Y, Pletnev, S, Verardi, R, Roederer, M, Kwong, P.D. | Deposit date: | 2022-09-07 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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6LAF
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![BU of 6laf by Molmil](/molmil-images/mine/6laf) | Crystal structure of the core domain of Amuc_1100 from Akkermansia muciniphila | Descriptor: | Amuc_1100, SULFATE ION | Authors: | Wang, J, Xiang, R, Zhang, M, Wang, M. | Deposit date: | 2019-11-12 | Release date: | 2020-08-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | The variable oligomeric state of Amuc_1100 from Akkermansia muciniphila. J.Struct.Biol., 212, 2020
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6VI0
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![BU of 6vi0 by Molmil](/molmil-images/mine/6vi0) | Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 gp120, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2020-01-10 | Release date: | 2021-01-13 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention. Mabs, 13
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6LZZ
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![BU of 6lzz by Molmil](/molmil-images/mine/6lzz) | Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a | Descriptor: | 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | Authors: | Huang, Y.Y, Wu, Y, Luo, H.B. | Deposit date: | 2020-02-19 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.40003753 Å) | Cite: | Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors To Be Published
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8F7T
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![BU of 8f7t by Molmil](/molmil-images/mine/8f7t) | Glycan-Base ConC Env Trimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env gp120, ... | Authors: | Olia, A.S, Kwong, P.D. | Deposit date: | 2022-11-20 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases. Iscience, 26, 2023
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6W03
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![BU of 6w03 by Molmil](/molmil-images/mine/6w03) | |
6VZI
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![BU of 6vzi by Molmil](/molmil-images/mine/6vzi) | |
8FLW
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![BU of 8flw by Molmil](/molmil-images/mine/8flw) | Cryo-EM Structure of PGT145 DU303 Fab in complex with BG505 DS-SOSIP.664 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2022-12-22 | Release date: | 2023-05-31 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design. Cell Rep, 42, 2023
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8FK5
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![BU of 8fk5 by Molmil](/molmil-images/mine/8fk5) | Cryo-EM Structure of PG9RSH DU011 Fab in complex with BG505 DS-SOSIP.664 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2022-12-20 | Release date: | 2023-05-31 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design. Cell Rep, 42, 2023
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8FR6
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![BU of 8fr6 by Molmil](/molmil-images/mine/8fr6) | Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Wang, S, Kwong, P.D. | Deposit date: | 2023-01-06 | Release date: | 2023-04-19 | Last modified: | 2023-06-07 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization. J.Virol., 97, 2023
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