8DUL

Cryo-EM Structure of Antibody SKT05 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles)

Summary for 8DUL

• Entry DOI: 10.2210/pdb8dul/pdb
• EMDB information: 27722
• Descriptor: Spike glycoprotein E2, Spike glycoprotein E1, Antibody Fab SKT05 heavy chain, ... (6 entities in total)
• Functional Keywords: antibody, skt05, western equine encephalitis virus, broadly neutralizing, immune system
• Biological source: Western equine encephalitis virus; More
• Total number of polymer chains: 8
• Total formula weight: 345547.66

Authors

Cerutti, G.,Verardi, R.,Roederer, M.,Shapiro, L. (deposition date: 2022-07-27, release date: 2023-07-05)

• Primary citation: Sutton, M.S.,Pletnev, S.,Callahan, V.,Ko, S.,Tsybovsky, Y.,Bylund, T.,Casner, R.G.,Cerutti, G.,Gardner, C.L.,Guirguis, V.,Verardi, R.,Zhang, B.,Ambrozak, D.,Beddall, M.,Lei, H.,Yang, E.S.,Liu, T.,Henry, A.R.,Rawi, R.,Schon, A.,Schramm, C.A.,Shen, C.H.,Shi, W.,Stephens, T.,Yang, Y.,Florez, M.B.,Ledgerwood, J.E.,Burke, C.W.,Shapiro, L.,Fox, J.M.,Kwong, P.D.,Roederer, M.; Vaccine elicitation and structural basis for antibody protection against alphaviruses.; Cell, 186:2672-2689.e25, 2023; PubMed: 37295404; DOI: 10.1016/j.cell.2023.05.019

Experimental method

ELECTRON MICROSCOPY (4.17 Å)