4YFL

Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120

Summary for 4YFL

• Entry DOI: 10.2210/pdb4yfl/pdb
• Descriptor: Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160, 1B2530 heavy chain, 1B2530 Light chain, ... (4 entities in total)
• Functional Keywords: hiv-1 cd4 binding site, broadly neutralizing antibody, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 176203.49

Authors

Acharya, P.,Zhou, T.,Moquin, S.,Kwong, P.D. (deposition date: 2015-02-25, release date: 2015-06-03, Last modification date: 2020-07-29)

• Primary citation: Zhou, T.,Lynch, R.M.,Chen, L.,Acharya, P.,Wu, X.,Doria-Rose, N.A.,Joyce, M.G.,Lingwood, D.,Soto, C.,Bailer, R.T.,Ernandes, M.J.,Kong, R.,Longo, N.S.,Louder, M.K.,McKee, K.,O'Dell, S.,Schmidt, S.D.,Tran, L.,Yang, Z.,Druz, A.,Luongo, T.S.,Moquin, S.,Srivatsan, S.,Yang, Y.,Zhang, B.,Zheng, A.,Pancera, M.,Kirys, T.,Georgiev, I.S.,Gindin, T.,Peng, H.P.,Yang, A.S.,Mullikin, J.C.,Gray, M.D.,Stamatatos, L.,Burton, D.R.,Koff, W.C.,Cohen, M.S.,Haynes, B.F.,Casazza, J.P.,Connors, M.,Corti, D.,Lanzavecchia, A.,Sattentau, Q.J.,Weiss, R.A.,West, A.P.,Bjorkman, P.J.,Scheid, J.F.,Nussenzweig, M.C.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.; Cell, 161:1280-1292, 2015; PubMed: 26004070; DOI: 10.1016/j.cell.2015.05.007

Experimental method

X-RAY DIFFRACTION (3.387 Å)