4YFL

Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (G, E)	Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160	polymer	353	39211.4	2	UniProt (Q0ED31) Pfam (PF00516)	Human immunodeficiency virus 1
2	B, E (H, F)	1B2530 heavy chain	polymer	227	24459.6	2		Homo sapiens (Human)
3	C, F (L, I)	1B2530 Light chain	polymer	215	22661.0	2		Homo sapiens (Human)
4	G, H, I, J, K... (G, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	16	Chemie (NAG)

Sequence modifications

G, E: 44 - 123 (UniProt: Q0ED31)
G, E: 199 - 301 (UniProt: Q0ED31)

PDB	External Database	Details
Gly 124	-	linker
Gly 198	-	linker

G, E: 324 - 492 (UniProt: Q0ED31)

PDB	External Database	Details
Gly 318	-	linker
Gly 319	-	linker
Ser 320	-	linker
Gly 321	-	linker
Ser 322	-	linker
Gly 323	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	172664.2
Non-Polymers*	Number of molecules	16
	Total formula weight	3539.3
All*	Total formula weight	176203.5

*Water molecules are not included.