6VZI

Crystal Structure of HIV-1 CAP256 RnS-3mut-2G-SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom

Summary for 6VZI

• Entry DOI: 10.2210/pdb6vzi/pdb
• Related: 6W03
• Descriptor: Envelope glycoprotein gp41, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: hiv-1 envelope prefusion trimer, entry inhibitors, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 154450.36

Authors

Lai, Y.-T.,Kwong, P.D. (deposition date: 2020-02-28, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Chuang, G.Y.,Lai, Y.T.,Boyington, J.C.,Cheng, C.,Geng, H.,Narpala, S.,Rawi, R.,Schmidt, S.D.,Tsybovsky, Y.,Verardi, R.,Xu, K.,Yang, Y.,Zhang, B.,Chambers, M.,Changela, A.,Corrigan, A.R.,Kong, R.,Olia, A.S.,Ou, L.,Sarfo, E.K.,Wang, S.,Wu, W.,Doria-Rose, N.A.,McDermott, A.B.,Mascola, J.R.,Kwong, P.D.; Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses.; J.Virol., 94:-, 2020; PubMed: 32295908; DOI: 10.1128/JVI.00074-20

Experimental method

X-RAY DIFFRACTION (2.716 Å)