7ELG

LC3B modificated with a covalent probe

Summary for 7ELG

Entry DOI	10.2210/pdb7elg/pdb
Descriptor	Microtubule-associated proteins 1A/1B light chain 3B, 2-methylidene-5-thiophen-2-yl-cyclohexane-1,3-dione, SULFATE ION, ... (4 entities in total)
Functional Keywords	inhibitor, complex, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14781.89
Authors	Fan, S.,Wan, W. (deposition date: 2021-04-10, release date: 2021-10-13, Last modification date: 2023-11-29)
Primary citation	Fan, S.,Yue, L.,Wan, W.,Zhang, Y.,Zhang, B.,Otomo, C.,Li, Q.,Lin, T.,Hu, J.,Xu, P.,Zhu, M.,Tao, H.,Chen, Z.,Li, L.,Ding, H.,Yao, Z.,Lu, J.,Wen, Y.,Zhang, N.,Tan, M.,Chen, K.,Xie, Y.,Otomo, T.,Zhou, B.,Jiang, H.,Dang, Y.,Luo, C. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew.Chem.Int.Ed.Engl., 60:26105-26114, 2021 Cited by PubMed: 34590387 DOI: 10.1002/anie.202109464 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.599 Å)

Structure validation