8DUN

Cryo-EM Structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles)

Summary for 8DUN

Entry DOI	10.2210/pdb8dun/pdb
EMDB information	27723
Descriptor	Antibody SKW11 heavy chain, Antibody SKW11 light chain, Spike glycoprotein E1, ... (6 entities in total)
Functional Keywords	antibody, skw11, western equine encephalitis virus, broadly neutralizing, immune system
Biological source	Macaca fascicularis More
Total number of polymer chains	12
Total formula weight	441076.92
Authors	Cerutti, G.,Verardi, R.,Roederer, M.,Shapiro, L. (deposition date: 2022-07-27, release date: 2023-07-05)
Primary citation	Sutton, M.S.,Pletnev, S.,Callahan, V.,Ko, S.,Tsybovsky, Y.,Bylund, T.,Casner, R.G.,Cerutti, G.,Gardner, C.L.,Guirguis, V.,Verardi, R.,Zhang, B.,Ambrozak, D.,Beddall, M.,Lei, H.,Yang, E.S.,Liu, T.,Henry, A.R.,Rawi, R.,Schon, A.,Schramm, C.A.,Shen, C.H.,Shi, W.,Stephens, T.,Yang, Y.,Florez, M.B.,Ledgerwood, J.E.,Burke, C.W.,Shapiro, L.,Fox, J.M.,Kwong, P.D.,Roederer, M. Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186:2672-2689.e25, 2023 Cited by PubMed: 37295404 DOI: 10.1016/j.cell.2023.05.019 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.84 Å)

Structure validation