7LTO
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![BU of 7lto by Molmil](/molmil-images/mine/7lto) | Nse5-6 complex | Descriptor: | Non-structural maintenance of chromosome element 5, Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera | Authors: | Yu, Y, Li, S.B, Zheng, S, Tangy, S, Koyi, C, Wan, B.B, Kung, H.H, Andrej, S, Alex, K, Patel, D.J, Zhao, X.L. | Deposit date: | 2021-02-19 | Release date: | 2021-05-19 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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6O6T
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![BU of 6o6t by Molmil](/molmil-images/mine/6o6t) | Crystal structure of Csm6 H132A mutant | Descriptor: | Csm6 | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
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6O75
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![BU of 6o75 by Molmil](/molmil-images/mine/6o75) | Crystal structure of Csm1-Csm4 cassette in complex with pppApA | Descriptor: | CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), Csm4, MANGANESE (II) ION, ... | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol.Cell, 75, 2019
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6O71
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![BU of 6o71 by Molmil](/molmil-images/mine/6o71) | |
6O7B
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![BU of 6o7b by Molmil](/molmil-images/mine/6o7b) | Crystal structure of Csm1-Csm4 cassette in complex with cA4 | Descriptor: | CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), Csm4, Cyclic RNA cA4 | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol.Cell, 75, 2019
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6OPF
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![BU of 6opf by Molmil](/molmil-images/mine/6opf) | |
6O6Y
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![BU of 6o6y by Molmil](/molmil-images/mine/6o6y) | Crystal structure of Csm6 in complex with cyclic-tetraadenylates (cA4) by cocrystallization of Csm6 and cA4 | Descriptor: | 2',3'- cyclic AMP, 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, Csm6 | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
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6O78
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![BU of 6o78 by Molmil](/molmil-images/mine/6o78) | Crystal structure of Csm1-Csm4 cassette in complex with pppApApA | Descriptor: | CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), Csm4, MANGANESE (II) ION, ... | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol.Cell, 75, 2019
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6O6V
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![BU of 6o6v by Molmil](/molmil-images/mine/6o6v) | |
6O73
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![BU of 6o73 by Molmil](/molmil-images/mine/6o73) | Crystal structure of apo Csm1-Csm4 cassette | Descriptor: | Csm1, Csm4, NICKEL (II) ION | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol.Cell, 75, 2019
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6O70
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![BU of 6o70 by Molmil](/molmil-images/mine/6o70) | Crystal structure of Csm6 H132A mutant in complex with cA4 by cocrystallization of cA4 and Csm6 H132A mutant | Descriptor: | 2',3'- cyclic AMP, 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, Csm6 | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
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6O47
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![BU of 6o47 by Molmil](/molmil-images/mine/6o47) | human cGAS core domain (K427E/K428E) bound with RU-521 | Descriptor: | (3~{S})-3-[1-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]-3~{H}-2-benzofuran-1-one, 2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one, CITRIC ACID, ... | Authors: | Xie, W, Lama, L, Adura, C, Glickman, J.F, Tuschl, T, Patel, D.J. | Deposit date: | 2019-02-28 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.196 Å) | Cite: | Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116, 2019
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6O6Z
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![BU of 6o6z by Molmil](/molmil-images/mine/6o6z) | Crystal structure of Csm6 H381A in complex with cA4 by cocrystallization of cA4 and Csm6 | Descriptor: | 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, Csm6 | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
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6O79
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![BU of 6o79 by Molmil](/molmil-images/mine/6o79) | Crystal structure of Csm1-Csm4 cassette in complex with cA3 | Descriptor: | CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), Csm4, cyclic RNA cA3 | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol.Cell, 75, 2019
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6O7E
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![BU of 6o7e by Molmil](/molmil-images/mine/6o7e) | |
6O7I
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![BU of 6o7i by Molmil](/molmil-images/mine/6o7i) | |
6O6X
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![BU of 6o6x by Molmil](/molmil-images/mine/6o6x) | |
6O6S
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![BU of 6o6s by Molmil](/molmil-images/mine/6o6s) | Crystal structure of Apo Csm6 | Descriptor: | Csm6 | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
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6O7H
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![BU of 6o7h by Molmil](/molmil-images/mine/6o7h) | |
6O74
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![BU of 6o74 by Molmil](/molmil-images/mine/6o74) | |
6O7D
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![BU of 6o7d by Molmil](/molmil-images/mine/6o7d) | Crystal structure of Csm1-Csm4 cassette in complex with one ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), Csm4, ... | Authors: | Jia, N, Patel, D.J. | Deposit date: | 2019-03-07 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol.Cell, 75, 2019
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6OV0
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![BU of 6ov0 by Molmil](/molmil-images/mine/6ov0) | |
6PPR
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![BU of 6ppr by Molmil](/molmil-images/mine/6ppr) | Cryo-EM structure of AdnA(D934A)-AdnB(D1014A) in complex with AMPPNP and DNA | Descriptor: | ATP-dependent DNA helicase (UvrD/REP), DNA (70-MER), IRON/SULFUR CLUSTER, ... | Authors: | Jia, N, Unciuleac, M, Shuman, S, Patel, D.J. | Deposit date: | 2019-07-08 | Release date: | 2019-11-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proc.Natl.Acad.Sci.USA, 116, 2019
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6PPJ
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![BU of 6ppj by Molmil](/molmil-images/mine/6ppj) | Cryo-EM structure of AdnA(D934A)-AdnB(D1014A) in complex with AMPPNP | Descriptor: | ATP-dependent DNA helicase (UvrD/REP), IRON/SULFUR CLUSTER, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jia, N, Unciuleac, M, Shuman, S, Patel, D.J. | Deposit date: | 2019-07-07 | Release date: | 2019-11-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proc.Natl.Acad.Sci.USA, 116, 2019
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6PPU
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![BU of 6ppu by Molmil](/molmil-images/mine/6ppu) | Cryo-EM structure of AdnAB-AMPPNP-DNA complex | Descriptor: | ATP-dependent DNA helicase (UvrD/REP), DNA (29-MER), IRON/SULFUR CLUSTER, ... | Authors: | Jia, N, Unciuleac, M, Shuman, S, Patel, D.J. | Deposit date: | 2019-07-08 | Release date: | 2019-11-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proc.Natl.Acad.Sci.USA, 116, 2019
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