6O47
human cGAS core domain (K427E/K428E) bound with RU-521
Summary for 6O47
Entry DOI | 10.2210/pdb6o47/pdb |
Descriptor | Cyclic GMP-AMP synthase, CITRIC ACID, ZINC ION, ... (6 entities in total) |
Functional Keywords | human, cgas, core domain, compound, ru-521, dna binding protein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 44766.16 |
Authors | Xie, W.,Lama, L.,Adura, C.,Glickman, J.F.,Tuschl, T.,Patel, D.J. (deposition date: 2019-02-28, release date: 2019-05-29, Last modification date: 2023-10-11) |
Primary citation | Xie, W.,Lama, L.,Adura, C.,Tomita, D.,Glickman, J.F.,Tuschl, T.,Patel, D.J. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116:11946-11955, 2019 Cited by PubMed: 31142647DOI: 10.1073/pnas.1905013116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.196 Å) |
Structure validation
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