6O47
human cGAS core domain (K427E/K428E) bound with RU-521
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 372 | 43486.0 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B, C (A) | CITRIC ACID | non-polymer | 192.1 | 2 | Chemie (CIT) | |||
| 3 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | E (A) | (3~{S})-3-[1-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]-3~{H}-2-benzofuran-1-one | non-polymer | 415.2 | 1 | Chemie (LLS) | |||
| 5 | F (A) | 2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one | non-polymer | 415.2 | 1 | Chemie (AEV) | |||
| 6 | G (A) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A: 152 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ser 151 | - | expression tag |
| Glu 427 | Lys 427 | engineered mutation |
| Glu 428 | Lys 428 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43486.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1280.1 | |
| All* | Total formula weight | 44766.2 |
